Phosphatase activity tunes two-component system sensor detection threshold

Two-component systems are a major family of signal transduction pathways and a rich source of sensors for biotechnology. Here, the authors develop a general method for rationally tuning two-component system input detection thresholds via specific point mutations in sensor histidine kinase proteins.

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Bibliographic Details
Main Authors: Brian P. Landry, Rohan Palanki, Nikola Dyulgyarov, Lucas A. Hartsough, Jeffrey J. Tabor
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Q
Online Access:https://doaj.org/article/a069825d5bfc4f6fb4d7b7972a4f7638
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