Phosphatase activity tunes two-component system sensor detection threshold

Two-component systems are a major family of signal transduction pathways and a rich source of sensors for biotechnology. Here, the authors develop a general method for rationally tuning two-component system input detection thresholds via specific point mutations in sensor histidine kinase proteins.

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Autores principales:	Brian P. Landry, Rohan Palanki, Nikola Dyulgyarov, Lucas A. Hartsough, Jeffrey J. Tabor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a069825d5bfc4f6fb4d7b7972a4f7638
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spelling	oai:doaj.org-article:a069825d5bfc4f6fb4d7b7972a4f76382021-12-02T15:34:26ZPhosphatase activity tunes two-component system sensor detection threshold10.1038/s41467-018-03929-y2041-1723https://doaj.org/article/a069825d5bfc4f6fb4d7b7972a4f76382018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03929-yhttps://doaj.org/toc/2041-1723Two-component systems are a major family of signal transduction pathways and a rich source of sensors for biotechnology. Here, the authors develop a general method for rationally tuning two-component system input detection thresholds via specific point mutations in sensor histidine kinase proteins.Brian P. LandryRohan PalankiNikola DyulgyarovLucas A. HartsoughJeffrey J. TaborNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brian P. Landry Rohan Palanki Nikola Dyulgyarov Lucas A. Hartsough Jeffrey J. Tabor Phosphatase activity tunes two-component system sensor detection threshold
description	Two-component systems are a major family of signal transduction pathways and a rich source of sensors for biotechnology. Here, the authors develop a general method for rationally tuning two-component system input detection thresholds via specific point mutations in sensor histidine kinase proteins.
format	article
author	Brian P. Landry Rohan Palanki Nikola Dyulgyarov Lucas A. Hartsough Jeffrey J. Tabor
author_facet	Brian P. Landry Rohan Palanki Nikola Dyulgyarov Lucas A. Hartsough Jeffrey J. Tabor
author_sort	Brian P. Landry
title	Phosphatase activity tunes two-component system sensor detection threshold
title_short	Phosphatase activity tunes two-component system sensor detection threshold
title_full	Phosphatase activity tunes two-component system sensor detection threshold
title_fullStr	Phosphatase activity tunes two-component system sensor detection threshold
title_full_unstemmed	Phosphatase activity tunes two-component system sensor detection threshold
title_sort	phosphatase activity tunes two-component system sensor detection threshold
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a069825d5bfc4f6fb4d7b7972a4f7638
work_keys_str_mv	AT brianplandry phosphataseactivitytunestwocomponentsystemsensordetectionthreshold AT rohanpalanki phosphataseactivitytunestwocomponentsystemsensordetectionthreshold AT nikoladyulgyarov phosphataseactivitytunestwocomponentsystemsensordetectionthreshold AT lucasahartsough phosphataseactivitytunestwocomponentsystemsensordetectionthreshold AT jeffreyjtabor phosphataseactivitytunestwocomponentsystemsensordetectionthreshold
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Phosphatase activity tunes two-component system sensor detection threshold

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