Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer

Using co-culture experiments and mathematical modelling, Paczkowski et al discover that prostate cancer spheroids comprising mixed tumour cell populations display enhanced growth and reduced radiation sensitivity due to competitive and antagonistic interactions between cell populations. This interdi...

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Autores principales:	Marcin Paczkowski, Warren W. Kretzschmar, Bostjan Markelc, Stanley K. Liu, Leoni A. Kunz-Schughart, Adrian L. Harris, Mike Partridge, Helen M. Byrne, Pavitra Kannan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a08140e263164d63ab72ee83c273ffdf
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spelling	oai:doaj.org-article:a08140e263164d63ab72ee83c273ffdf2021-12-02T15:07:32ZReciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer10.1038/s42003-020-01529-52399-3642https://doaj.org/article/a08140e263164d63ab72ee83c273ffdf2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01529-5https://doaj.org/toc/2399-3642Using co-culture experiments and mathematical modelling, Paczkowski et al discover that prostate cancer spheroids comprising mixed tumour cell populations display enhanced growth and reduced radiation sensitivity due to competitive and antagonistic interactions between cell populations. This interdisciplinary approach reveals a role for ecological-type interactions in the radiation response and may be used to study other cancer types.Marcin PaczkowskiWarren W. KretzschmarBostjan MarkelcStanley K. LiuLeoni A. Kunz-SchughartAdrian L. HarrisMike PartridgeHelen M. ByrnePavitra KannanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Marcin Paczkowski Warren W. Kretzschmar Bostjan Markelc Stanley K. Liu Leoni A. Kunz-Schughart Adrian L. Harris Mike Partridge Helen M. Byrne Pavitra Kannan Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer
description	Using co-culture experiments and mathematical modelling, Paczkowski et al discover that prostate cancer spheroids comprising mixed tumour cell populations display enhanced growth and reduced radiation sensitivity due to competitive and antagonistic interactions between cell populations. This interdisciplinary approach reveals a role for ecological-type interactions in the radiation response and may be used to study other cancer types.
format	article
author	Marcin Paczkowski Warren W. Kretzschmar Bostjan Markelc Stanley K. Liu Leoni A. Kunz-Schughart Adrian L. Harris Mike Partridge Helen M. Byrne Pavitra Kannan
author_facet	Marcin Paczkowski Warren W. Kretzschmar Bostjan Markelc Stanley K. Liu Leoni A. Kunz-Schughart Adrian L. Harris Mike Partridge Helen M. Byrne Pavitra Kannan
author_sort	Marcin Paczkowski
title	Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer
title_short	Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer
title_full	Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer
title_fullStr	Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer
title_full_unstemmed	Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer
title_sort	reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a08140e263164d63ab72ee83c273ffdf
work_keys_str_mv	AT marcinpaczkowski reciprocalinteractionsbetweentumourcellpopulationsenhancegrowthandreduceradiationsensitivityinprostatecancer AT warrenwkretzschmar reciprocalinteractionsbetweentumourcellpopulationsenhancegrowthandreduceradiationsensitivityinprostatecancer AT bostjanmarkelc reciprocalinteractionsbetweentumourcellpopulationsenhancegrowthandreduceradiationsensitivityinprostatecancer AT stanleykliu reciprocalinteractionsbetweentumourcellpopulationsenhancegrowthandreduceradiationsensitivityinprostatecancer AT leoniakunzschughart reciprocalinteractionsbetweentumourcellpopulationsenhancegrowthandreduceradiationsensitivityinprostatecancer AT adrianlharris reciprocalinteractionsbetweentumourcellpopulationsenhancegrowthandreduceradiationsensitivityinprostatecancer AT mikepartridge reciprocalinteractionsbetweentumourcellpopulationsenhancegrowthandreduceradiationsensitivityinprostatecancer AT helenmbyrne reciprocalinteractionsbetweentumourcellpopulationsenhancegrowthandreduceradiationsensitivityinprostatecancer AT pavitrakannan reciprocalinteractionsbetweentumourcellpopulationsenhancegrowthandreduceradiationsensitivityinprostatecancer
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Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer

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