Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and antibacterial compounds forS. aureus, A. baumannii and...

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Autores principales:	Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a0c4424f2eeb46a689586e4828ae7887
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spelling	oai:doaj.org-article:a0c4424f2eeb46a689586e4828ae78872021-12-02T15:38:42ZPrioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening10.1038/ncomms160812041-1723https://doaj.org/article/a0c4424f2eeb46a689586e4828ae78872017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16081https://doaj.org/toc/2041-1723Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and antibacterial compounds forS. aureus, A. baumannii and M. tuberculosis.Carl A. MachuttaChristopher S. KollmannKenneth E. LindXiaopeng BaiPan F. ChanJianzhong HuangLluis BallellSvetlana BelyanskayaGurdyal S. BesraDavid Barros-AguirreRobert H. BatesPaolo A. CentrellaSandy S. ChangJing ChaiAnthony E. ChoudhryAaron CoffinChristopher P. DavieHongfeng DengJianghe DengYun DingJason W. DodsonDavid T. FosbennerEnoch N. GaoTaylor L. GrahamTodd L. GraybillKaren IngrahamWalter P. JohnsonBryan W. KingChristopher R. KwiatkowskiJoël LelièvreYue LiXiaorong LiuQuinn LuRuth LehrAlfonso Mendoza-LosanaJohn MartinLynn McCloskeyPatti McCormickHeather P. O’KeefeThomas O’KeeffeChristina PaoChristopher B. PhelpsHongwei QiKeith RaffertyGenaro S. ScavelloMatt S. SteigingaFlora S. SundersinghSharon M. SweitzerLawrence M. SzewczukAmy TaylorMay Fern TohJuan WangMinghui WangDevan J. WilkinsBing XiaGang YaoJean ZhangJingye ZhouChristine P. DonahueJeffrey A. MesserDavid HolmesChristopher C. Arico-MuendelAndrew J. PopeJeffrey W. GrossGhotas EvindarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carl A. Machutta Christopher S. Kollmann Kenneth E. Lind Xiaopeng Bai Pan F. Chan Jianzhong Huang Lluis Ballell Svetlana Belyanskaya Gurdyal S. Besra David Barros-Aguirre Robert H. Bates Paolo A. Centrella Sandy S. Chang Jing Chai Anthony E. Choudhry Aaron Coffin Christopher P. Davie Hongfeng Deng Jianghe Deng Yun Ding Jason W. Dodson David T. Fosbenner Enoch N. Gao Taylor L. Graham Todd L. Graybill Karen Ingraham Walter P. Johnson Bryan W. King Christopher R. Kwiatkowski Joël Lelièvre Yue Li Xiaorong Liu Quinn Lu Ruth Lehr Alfonso Mendoza-Losana John Martin Lynn McCloskey Patti McCormick Heather P. O’Keefe Thomas O’Keeffe Christina Pao Christopher B. Phelps Hongwei Qi Keith Rafferty Genaro S. Scavello Matt S. Steiginga Flora S. Sundersingh Sharon M. Sweitzer Lawrence M. Szewczuk Amy Taylor May Fern Toh Juan Wang Minghui Wang Devan J. Wilkins Bing Xia Gang Yao Jean Zhang Jingye Zhou Christine P. Donahue Jeffrey A. Messer David Holmes Christopher C. Arico-Muendel Andrew J. Pope Jeffrey W. Gross Ghotas Evindar Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
description	Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and antibacterial compounds forS. aureus, A. baumannii and M. tuberculosis.
format	article
author	Carl A. Machutta Christopher S. Kollmann Kenneth E. Lind Xiaopeng Bai Pan F. Chan Jianzhong Huang Lluis Ballell Svetlana Belyanskaya Gurdyal S. Besra David Barros-Aguirre Robert H. Bates Paolo A. Centrella Sandy S. Chang Jing Chai Anthony E. Choudhry Aaron Coffin Christopher P. Davie Hongfeng Deng Jianghe Deng Yun Ding Jason W. Dodson David T. Fosbenner Enoch N. Gao Taylor L. Graham Todd L. Graybill Karen Ingraham Walter P. Johnson Bryan W. King Christopher R. Kwiatkowski Joël Lelièvre Yue Li Xiaorong Liu Quinn Lu Ruth Lehr Alfonso Mendoza-Losana John Martin Lynn McCloskey Patti McCormick Heather P. O’Keefe Thomas O’Keeffe Christina Pao Christopher B. Phelps Hongwei Qi Keith Rafferty Genaro S. Scavello Matt S. Steiginga Flora S. Sundersingh Sharon M. Sweitzer Lawrence M. Szewczuk Amy Taylor May Fern Toh Juan Wang Minghui Wang Devan J. Wilkins Bing Xia Gang Yao Jean Zhang Jingye Zhou Christine P. Donahue Jeffrey A. Messer David Holmes Christopher C. Arico-Muendel Andrew J. Pope Jeffrey W. Gross Ghotas Evindar
author_facet	Carl A. Machutta Christopher S. Kollmann Kenneth E. Lind Xiaopeng Bai Pan F. Chan Jianzhong Huang Lluis Ballell Svetlana Belyanskaya Gurdyal S. Besra David Barros-Aguirre Robert H. Bates Paolo A. Centrella Sandy S. Chang Jing Chai Anthony E. Choudhry Aaron Coffin Christopher P. Davie Hongfeng Deng Jianghe Deng Yun Ding Jason W. Dodson David T. Fosbenner Enoch N. Gao Taylor L. Graham Todd L. Graybill Karen Ingraham Walter P. Johnson Bryan W. King Christopher R. Kwiatkowski Joël Lelièvre Yue Li Xiaorong Liu Quinn Lu Ruth Lehr Alfonso Mendoza-Losana John Martin Lynn McCloskey Patti McCormick Heather P. O’Keefe Thomas O’Keeffe Christina Pao Christopher B. Phelps Hongwei Qi Keith Rafferty Genaro S. Scavello Matt S. Steiginga Flora S. Sundersingh Sharon M. Sweitzer Lawrence M. Szewczuk Amy Taylor May Fern Toh Juan Wang Minghui Wang Devan J. Wilkins Bing Xia Gang Yao Jean Zhang Jingye Zhou Christine P. Donahue Jeffrey A. Messer David Holmes Christopher C. Arico-Muendel Andrew J. Pope Jeffrey W. Gross Ghotas Evindar
author_sort	Carl A. Machutta
title	Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
title_short	Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
title_full	Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
title_fullStr	Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
title_full_unstemmed	Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
title_sort	prioritizing multiple therapeutic targets in parallel using automated dna-encoded library screening
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a0c4424f2eeb46a689586e4828ae7887
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Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

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