Mutations targeting the coagulation pathway are enriched in brain metastases

Mutations targeting the coagulation pathway are enriched in brain metastases

Abstract Brain metastases (BMs) are the most common malignancy of the central nervous system. Recently it has been demonstrated that plasminogen activator inhibitor serpins promote brain metastatic colonization, suggesting that mutations in serpins or other members of the coagulation cascade can pro...

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Main Authors: Cristina Richichi, Lorenzo Fornasari, Giorgio E. M. Melloni, Paola Brescia, Monica Patanè, Massimiliano Del Bene, Dana A. M. Mustafa, Johan M. Kros, Bianca Pollo, Giancarlo Pruneri, Angela Sciandivasci, Elisabetta Munzone, Francesco DiMeco, Pier Giuseppe Pelicci, Laura Riva, Giuliana Pelicci
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/a0eaf788c4784e3b8d5d5bc618c6c73f
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https://doaj.org/article/a0eaf788c4784e3b8d5d5bc618c6c73f

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