iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
p53 is able to induce ferroptosis in response to reactive oxygen species (ROS)-induced stress and suppresses tumour growth. Here, the authors show that iPLA2β suppresses p53-medated ferroptosis by cleaving and detoxifying peroxidized lipids and that this is independent of canonical ferroptosis regul...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
|
| Subjects: | |
| Online Access: | https://doaj.org/article/a120a8ca7a5849038e10bdd49256abdc |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|