iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

p53 is able to induce ferroptosis in response to reactive oxygen species (ROS)-induced stress and suppresses tumour growth. Here, the authors show that iPLA2β suppresses p53-medated ferroptosis by cleaving and detoxifying peroxidized lipids and that this is independent of canonical ferroptosis regul...

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Autores principales:	Delin Chen, Bo Chu, Xin Yang, Zhaoqi Liu, Ying Jin, Ning Kon, Raul Rabadan, Xuejun Jiang, Brent R. Stockwell, Wei Gu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a120a8ca7a5849038e10bdd49256abdc
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spelling	oai:doaj.org-article:a120a8ca7a5849038e10bdd49256abdc2021-12-02T16:04:12ZiPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX410.1038/s41467-021-23902-62041-1723https://doaj.org/article/a120a8ca7a5849038e10bdd49256abdc2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23902-6https://doaj.org/toc/2041-1723p53 is able to induce ferroptosis in response to reactive oxygen species (ROS)-induced stress and suppresses tumour growth. Here, the authors show that iPLA2β suppresses p53-medated ferroptosis by cleaving and detoxifying peroxidized lipids and that this is independent of canonical ferroptosis regulator GPX4.Delin ChenBo ChuXin YangZhaoqi LiuYing JinNing KonRaul RabadanXuejun JiangBrent R. StockwellWei GuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Delin Chen Bo Chu Xin Yang Zhaoqi Liu Ying Jin Ning Kon Raul Rabadan Xuejun Jiang Brent R. Stockwell Wei Gu iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
description	p53 is able to induce ferroptosis in response to reactive oxygen species (ROS)-induced stress and suppresses tumour growth. Here, the authors show that iPLA2β suppresses p53-medated ferroptosis by cleaving and detoxifying peroxidized lipids and that this is independent of canonical ferroptosis regulator GPX4.
format	article
author	Delin Chen Bo Chu Xin Yang Zhaoqi Liu Ying Jin Ning Kon Raul Rabadan Xuejun Jiang Brent R. Stockwell Wei Gu
author_facet	Delin Chen Bo Chu Xin Yang Zhaoqi Liu Ying Jin Ning Kon Raul Rabadan Xuejun Jiang Brent R. Stockwell Wei Gu
author_sort	Delin Chen
title	iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
title_short	iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
title_full	iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
title_fullStr	iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
title_full_unstemmed	iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4
title_sort	ipla2β-mediated lipid detoxification controls p53-driven ferroptosis independent of gpx4
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a120a8ca7a5849038e10bdd49256abdc
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_version_	1718385290314252288

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

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