Amyloid-mediated sequestration of essential proteins contributes to mutant huntingtin toxicity in yeast.

<h4>Background</h4>Polyglutamine expansion is responsible for several neurodegenerative disorders, among which Huntington disease is the most well-known. Studies in the yeast model demonstrated that both aggregation and toxicity of a huntingtin (htt) protein with an expanded polyglutamin...

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Autores principales: Natalia V Kochneva-Pervukhova, Alexander I Alexandrov, Michael D Ter-Avanesyan
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/a126f683c7864c849bda5424748fc5ef
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