Amyloid-mediated sequestration of essential proteins contributes to mutant huntingtin toxicity in yeast.
<h4>Background</h4>Polyglutamine expansion is responsible for several neurodegenerative disorders, among which Huntington disease is the most well-known. Studies in the yeast model demonstrated that both aggregation and toxicity of a huntingtin (htt) protein with an expanded polyglutamin...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
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| Acceso en línea: | https://doaj.org/article/a126f683c7864c849bda5424748fc5ef |
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