Amyloid-mediated sequestration of essential proteins contributes to mutant huntingtin toxicity in yeast.
<h4>Background</h4>Polyglutamine expansion is responsible for several neurodegenerative disorders, among which Huntington disease is the most well-known. Studies in the yeast model demonstrated that both aggregation and toxicity of a huntingtin (htt) protein with an expanded polyglutamin...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Public Library of Science (PLoS)
2012
|
| Subjects: | |
| Online Access: | https://doaj.org/article/a126f683c7864c849bda5424748fc5ef |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Be the first to leave a comment!