Enhanced Enterovirus D68 Replication in Neuroblastoma Cells Is Associated with a Cell Culture-Adaptive Amino Acid Substitution in VP1

Enhanced Enterovirus D68 Replication in Neuroblastoma Cells Is Associated with a Cell Culture-Adaptive Amino Acid Substitution in VP1

ABSTRACT Since its emergence in the United States in 2014, enterovirus D68 (EV-D68) has been and is associated with severe respiratory diseases and acute flaccid myelitis. Even though EV-D68 has been shown to replicate in different neuronal cells in vitro, it is currently poorly understood which vir...

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Autores principales: Syriam Sooksawasdi Na Ayudhya, Adam Meijer, Lisa Bauer, Bas Oude Munnink, Carmen Embregts, Lonneke Leijten, Jurre Y. Siegers, Brigitta M. Laksono, Frank van Kuppeveld, Thijs Kuiken, Corine GeurtsvanKessel, Debby van Riel
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
VP1
cell culture adaptation
enterovirus D68
heparan sulfate
in vitro
neuroblastoma cells
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/a12b94232b714cbd952b775fd27861fa
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https://doaj.org/article/a12b94232b714cbd952b775fd27861fa

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