Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
IL-10 production by B cells is integral to regulation and resolution of inflammation. Here the authors show that cholesterol metabolism can control B cell IL-10 production via a geranylgeranyl pyrophosphate-dependent mechanism.
Guardado en:
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/a13c8e4f4fa14c78ae7364c2bdf52f9c |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:a13c8e4f4fa14c78ae7364c2bdf52f9c |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:a13c8e4f4fa14c78ae7364c2bdf52f9c2021-12-02T15:23:00ZCholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate10.1038/s41467-020-17179-42041-1723https://doaj.org/article/a13c8e4f4fa14c78ae7364c2bdf52f9c2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17179-4https://doaj.org/toc/2041-1723IL-10 production by B cells is integral to regulation and resolution of inflammation. Here the authors show that cholesterol metabolism can control B cell IL-10 production via a geranylgeranyl pyrophosphate-dependent mechanism.Jack A. BibbyHarriet A. PurvisThomas HaydayAnita ChandraKlaus OkkenhaugSofia RosenzweigIvona AksentijevichMichael WoodHelen J. LachmannClaudia KemperAndrew P. CopeEsperanza PeruchaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Jack A. Bibby Harriet A. Purvis Thomas Hayday Anita Chandra Klaus Okkenhaug Sofia Rosenzweig Ivona Aksentijevich Michael Wood Helen J. Lachmann Claudia Kemper Andrew P. Cope Esperanza Perucha Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate |
description |
IL-10 production by B cells is integral to regulation and resolution of inflammation. Here the authors show that cholesterol metabolism can control B cell IL-10 production via a geranylgeranyl pyrophosphate-dependent mechanism. |
format |
article |
author |
Jack A. Bibby Harriet A. Purvis Thomas Hayday Anita Chandra Klaus Okkenhaug Sofia Rosenzweig Ivona Aksentijevich Michael Wood Helen J. Lachmann Claudia Kemper Andrew P. Cope Esperanza Perucha |
author_facet |
Jack A. Bibby Harriet A. Purvis Thomas Hayday Anita Chandra Klaus Okkenhaug Sofia Rosenzweig Ivona Aksentijevich Michael Wood Helen J. Lachmann Claudia Kemper Andrew P. Cope Esperanza Perucha |
author_sort |
Jack A. Bibby |
title |
Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate |
title_short |
Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate |
title_full |
Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate |
title_fullStr |
Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate |
title_full_unstemmed |
Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate |
title_sort |
cholesterol metabolism drives regulatory b cell il-10 through provision of geranylgeranyl pyrophosphate |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/a13c8e4f4fa14c78ae7364c2bdf52f9c |
work_keys_str_mv |
AT jackabibby cholesterolmetabolismdrivesregulatorybcellil10throughprovisionofgeranylgeranylpyrophosphate AT harrietapurvis cholesterolmetabolismdrivesregulatorybcellil10throughprovisionofgeranylgeranylpyrophosphate AT thomashayday cholesterolmetabolismdrivesregulatorybcellil10throughprovisionofgeranylgeranylpyrophosphate AT anitachandra cholesterolmetabolismdrivesregulatorybcellil10throughprovisionofgeranylgeranylpyrophosphate AT klausokkenhaug cholesterolmetabolismdrivesregulatorybcellil10throughprovisionofgeranylgeranylpyrophosphate AT sofiarosenzweig cholesterolmetabolismdrivesregulatorybcellil10throughprovisionofgeranylgeranylpyrophosphate AT ivonaaksentijevich cholesterolmetabolismdrivesregulatorybcellil10throughprovisionofgeranylgeranylpyrophosphate AT michaelwood cholesterolmetabolismdrivesregulatorybcellil10throughprovisionofgeranylgeranylpyrophosphate AT helenjlachmann cholesterolmetabolismdrivesregulatorybcellil10throughprovisionofgeranylgeranylpyrophosphate AT claudiakemper cholesterolmetabolismdrivesregulatorybcellil10throughprovisionofgeranylgeranylpyrophosphate AT andrewpcope cholesterolmetabolismdrivesregulatorybcellil10throughprovisionofgeranylgeranylpyrophosphate AT esperanzaperucha cholesterolmetabolismdrivesregulatorybcellil10throughprovisionofgeranylgeranylpyrophosphate |
_version_ |
1718387343694495744 |