Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

IL-10 production by B cells is integral to regulation and resolution of inflammation. Here the authors show that cholesterol metabolism can control B cell IL-10 production via a geranylgeranyl pyrophosphate-dependent mechanism.

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Autores principales: Jack A. Bibby, Harriet A. Purvis, Thomas Hayday, Anita Chandra, Klaus Okkenhaug, Sofia Rosenzweig, Ivona Aksentijevich, Michael Wood, Helen J. Lachmann, Claudia Kemper, Andrew P. Cope, Esperanza Perucha
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a13c8e4f4fa14c78ae7364c2bdf52f9c
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spelling oai:doaj.org-article:a13c8e4f4fa14c78ae7364c2bdf52f9c2021-12-02T15:23:00ZCholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate10.1038/s41467-020-17179-42041-1723https://doaj.org/article/a13c8e4f4fa14c78ae7364c2bdf52f9c2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17179-4https://doaj.org/toc/2041-1723IL-10 production by B cells is integral to regulation and resolution of inflammation. Here the authors show that cholesterol metabolism can control B cell IL-10 production via a geranylgeranyl pyrophosphate-dependent mechanism.Jack A. BibbyHarriet A. PurvisThomas HaydayAnita ChandraKlaus OkkenhaugSofia RosenzweigIvona AksentijevichMichael WoodHelen J. LachmannClaudia KemperAndrew P. CopeEsperanza PeruchaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jack A. Bibby
Harriet A. Purvis
Thomas Hayday
Anita Chandra
Klaus Okkenhaug
Sofia Rosenzweig
Ivona Aksentijevich
Michael Wood
Helen J. Lachmann
Claudia Kemper
Andrew P. Cope
Esperanza Perucha
Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
description IL-10 production by B cells is integral to regulation and resolution of inflammation. Here the authors show that cholesterol metabolism can control B cell IL-10 production via a geranylgeranyl pyrophosphate-dependent mechanism.
format article
author Jack A. Bibby
Harriet A. Purvis
Thomas Hayday
Anita Chandra
Klaus Okkenhaug
Sofia Rosenzweig
Ivona Aksentijevich
Michael Wood
Helen J. Lachmann
Claudia Kemper
Andrew P. Cope
Esperanza Perucha
author_facet Jack A. Bibby
Harriet A. Purvis
Thomas Hayday
Anita Chandra
Klaus Okkenhaug
Sofia Rosenzweig
Ivona Aksentijevich
Michael Wood
Helen J. Lachmann
Claudia Kemper
Andrew P. Cope
Esperanza Perucha
author_sort Jack A. Bibby
title Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
title_short Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
title_full Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
title_fullStr Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
title_full_unstemmed Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
title_sort cholesterol metabolism drives regulatory b cell il-10 through provision of geranylgeranyl pyrophosphate
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/a13c8e4f4fa14c78ae7364c2bdf52f9c
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