Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning

The pregnane X receptor (PXR, <i>NR1I2</i>) is a nuclear receptor which exerts its regulatory function by heterodimerization with the retinoid-X-receptor α (RXRα, <i>NR2B1</i>) and binding to the promoter and enhancer regions of diverse target genes. PXR is involved in the re...

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Autores principales: Juan Pablo Rigalli, Dirk Theile, Julie Nilles, Johanna Weiss
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/a1554bc0021e43bca23c40e3b7c676fd
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