Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

Inhibition of the lipid peroxidase GPX4 promotes ferroptotic cell death. Here, the authors identify a complementary approach using conjugated linolenic fatty acids that trigger lipid peroxidation and ferroptosis via ACSL1, DGAT1/2, and neutral lipids.

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Autores principales:	Alexander Beatty, Tanu Singh, Yulia Y. Tyurina, Vladimir A. Tyurin, Svetlana Samovich, Emmanuelle Nicolas, Kristen Maslar, Yan Zhou, Kathy Q. Cai, Yinfei Tan, Sebastian Doll, Marcus Conrad, Aravind Subramanian, Hülya Bayır, Valerian E. Kagan, Ulrike Rennefahrt, Jeffrey R. Peterson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a15fa8f172aa4a2c98e5449033292272
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spelling	oai:doaj.org-article:a15fa8f172aa4a2c98e54490332922722021-12-02T14:25:17ZFerroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL110.1038/s41467-021-22471-y2041-1723https://doaj.org/article/a15fa8f172aa4a2c98e54490332922722021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22471-yhttps://doaj.org/toc/2041-1723Inhibition of the lipid peroxidase GPX4 promotes ferroptotic cell death. Here, the authors identify a complementary approach using conjugated linolenic fatty acids that trigger lipid peroxidation and ferroptosis via ACSL1, DGAT1/2, and neutral lipids.Alexander BeattyTanu SinghYulia Y. TyurinaVladimir A. TyurinSvetlana SamovichEmmanuelle NicolasKristen MaslarYan ZhouKathy Q. CaiYinfei TanSebastian DollMarcus ConradAravind SubramanianHülya BayırValerian E. KaganUlrike RennefahrtJeffrey R. PetersonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander Beatty Tanu Singh Yulia Y. Tyurina Vladimir A. Tyurin Svetlana Samovich Emmanuelle Nicolas Kristen Maslar Yan Zhou Kathy Q. Cai Yinfei Tan Sebastian Doll Marcus Conrad Aravind Subramanian Hülya Bayır Valerian E. Kagan Ulrike Rennefahrt Jeffrey R. Peterson Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
description	Inhibition of the lipid peroxidase GPX4 promotes ferroptotic cell death. Here, the authors identify a complementary approach using conjugated linolenic fatty acids that trigger lipid peroxidation and ferroptosis via ACSL1, DGAT1/2, and neutral lipids.
format	article
author	Alexander Beatty Tanu Singh Yulia Y. Tyurina Vladimir A. Tyurin Svetlana Samovich Emmanuelle Nicolas Kristen Maslar Yan Zhou Kathy Q. Cai Yinfei Tan Sebastian Doll Marcus Conrad Aravind Subramanian Hülya Bayır Valerian E. Kagan Ulrike Rennefahrt Jeffrey R. Peterson
author_facet	Alexander Beatty Tanu Singh Yulia Y. Tyurina Vladimir A. Tyurin Svetlana Samovich Emmanuelle Nicolas Kristen Maslar Yan Zhou Kathy Q. Cai Yinfei Tan Sebastian Doll Marcus Conrad Aravind Subramanian Hülya Bayır Valerian E. Kagan Ulrike Rennefahrt Jeffrey R. Peterson
author_sort	Alexander Beatty
title	Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
title_short	Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
title_full	Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
title_fullStr	Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
title_full_unstemmed	Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
title_sort	ferroptotic cell death triggered by conjugated linolenic acids is mediated by acsl1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a15fa8f172aa4a2c98e5449033292272
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Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

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