Phlpp1 is induced by estrogen in osteoclasts and its loss in Ctsk-expressing cells does not protect against ovariectomy-induced bone loss.

Prior studies demonstrated that deletion of the protein phosphatase Phlpp1 in Ctsk-Cre expressing cells enhances bone mass, characterized by diminished osteoclast activity and increased coupling to bone formation. Due to non-specific expression of Ctsk-Cre, the definitive mechanism for this observat...

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Auteurs principaux: Marcelline K Hanson, Ismael Y Karkache, David H H Molstad, Andrew A Norton, Kim C Mansky, Elizabeth W Bradley
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2021
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Accès en ligne:https://doaj.org/article/a1676eb44dfb4341bb44d713ce62da0b
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