Senescent tumor cells lead the collective invasion in thyroid cancer

The senescence-associated secretory phenotype of stromal cells can promote tumorigenesis. Here, the authors show that senescent cancer cells are localized at the invasive front in human papillary thyroid carcinoma, and that senescent cancer cells drive collective invasion via CXCL12 in mouse models.

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Autores principales: Young Hwa Kim, Yong Won Choi, Jeonghun Lee, Euy Young Soh, Jang-Hee Kim, Tae Jun Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/a1727d7379fe4b139d6b4efb24d9bee8
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