Senescent tumor cells lead the collective invasion in thyroid cancer

The senescence-associated secretory phenotype of stromal cells can promote tumorigenesis. Here, the authors show that senescent cancer cells are localized at the invasive front in human papillary thyroid carcinoma, and that senescent cancer cells drive collective invasion via CXCL12 in mouse models.

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Bibliographic Details
Main Authors:	Young Hwa Kim, Yong Won Choi, Jeonghun Lee, Euy Young Soh, Jang-Hee Kim, Tae Jun Park
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/a1727d7379fe4b139d6b4efb24d9bee8
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spelling	oai:doaj.org-article:a1727d7379fe4b139d6b4efb24d9bee82021-12-02T15:37:02ZSenescent tumor cells lead the collective invasion in thyroid cancer10.1038/ncomms152082041-1723https://doaj.org/article/a1727d7379fe4b139d6b4efb24d9bee82017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15208https://doaj.org/toc/2041-1723The senescence-associated secretory phenotype of stromal cells can promote tumorigenesis. Here, the authors show that senescent cancer cells are localized at the invasive front in human papillary thyroid carcinoma, and that senescent cancer cells drive collective invasion via CXCL12 in mouse models.Young Hwa KimYong Won ChoiJeonghun LeeEuy Young SohJang-Hee KimTae Jun ParkNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Young Hwa Kim Yong Won Choi Jeonghun Lee Euy Young Soh Jang-Hee Kim Tae Jun Park Senescent tumor cells lead the collective invasion in thyroid cancer
description	The senescence-associated secretory phenotype of stromal cells can promote tumorigenesis. Here, the authors show that senescent cancer cells are localized at the invasive front in human papillary thyroid carcinoma, and that senescent cancer cells drive collective invasion via CXCL12 in mouse models.
format	article
author	Young Hwa Kim Yong Won Choi Jeonghun Lee Euy Young Soh Jang-Hee Kim Tae Jun Park
author_facet	Young Hwa Kim Yong Won Choi Jeonghun Lee Euy Young Soh Jang-Hee Kim Tae Jun Park
author_sort	Young Hwa Kim
title	Senescent tumor cells lead the collective invasion in thyroid cancer
title_short	Senescent tumor cells lead the collective invasion in thyroid cancer
title_full	Senescent tumor cells lead the collective invasion in thyroid cancer
title_fullStr	Senescent tumor cells lead the collective invasion in thyroid cancer
title_full_unstemmed	Senescent tumor cells lead the collective invasion in thyroid cancer
title_sort	senescent tumor cells lead the collective invasion in thyroid cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a1727d7379fe4b139d6b4efb24d9bee8
work_keys_str_mv	AT younghwakim senescenttumorcellsleadthecollectiveinvasioninthyroidcancer AT yongwonchoi senescenttumorcellsleadthecollectiveinvasioninthyroidcancer AT jeonghunlee senescenttumorcellsleadthecollectiveinvasioninthyroidcancer AT euyyoungsoh senescenttumorcellsleadthecollectiveinvasioninthyroidcancer AT jangheekim senescenttumorcellsleadthecollectiveinvasioninthyroidcancer AT taejunpark senescenttumorcellsleadthecollectiveinvasioninthyroidcancer
_version_	1718386249211838464

Senescent tumor cells lead the collective invasion in thyroid cancer

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