Promoter-proximal pausing mediated by the exon junction complex regulates splicing

The exon junction complex (EJC) has been identified as functioning as a post-transcriptional gene regulator. Here the authors reveal that the complex also plays a part in the regulation of transcription by regulating the release of Pol II pausing into transcription elongation.

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Autores principales:	Junaid Akhtar, Nastasja Kreim, Federico Marini, Giriram Mohana, Daniel Brüne, Harald Binder, Jean-Yves Roignant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a1b644d0069147debd628820b07cf1c2
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spelling	oai:doaj.org-article:a1b644d0069147debd628820b07cf1c22021-12-02T17:02:12ZPromoter-proximal pausing mediated by the exon junction complex regulates splicing10.1038/s41467-019-08381-02041-1723https://doaj.org/article/a1b644d0069147debd628820b07cf1c22019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08381-0https://doaj.org/toc/2041-1723The exon junction complex (EJC) has been identified as functioning as a post-transcriptional gene regulator. Here the authors reveal that the complex also plays a part in the regulation of transcription by regulating the release of Pol II pausing into transcription elongation.Junaid AkhtarNastasja KreimFederico MariniGiriram MohanaDaniel BrüneHarald BinderJean-Yves RoignantNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junaid Akhtar Nastasja Kreim Federico Marini Giriram Mohana Daniel Brüne Harald Binder Jean-Yves Roignant Promoter-proximal pausing mediated by the exon junction complex regulates splicing
description	The exon junction complex (EJC) has been identified as functioning as a post-transcriptional gene regulator. Here the authors reveal that the complex also plays a part in the regulation of transcription by regulating the release of Pol II pausing into transcription elongation.
format	article
author	Junaid Akhtar Nastasja Kreim Federico Marini Giriram Mohana Daniel Brüne Harald Binder Jean-Yves Roignant
author_facet	Junaid Akhtar Nastasja Kreim Federico Marini Giriram Mohana Daniel Brüne Harald Binder Jean-Yves Roignant
author_sort	Junaid Akhtar
title	Promoter-proximal pausing mediated by the exon junction complex regulates splicing
title_short	Promoter-proximal pausing mediated by the exon junction complex regulates splicing
title_full	Promoter-proximal pausing mediated by the exon junction complex regulates splicing
title_fullStr	Promoter-proximal pausing mediated by the exon junction complex regulates splicing
title_full_unstemmed	Promoter-proximal pausing mediated by the exon junction complex regulates splicing
title_sort	promoter-proximal pausing mediated by the exon junction complex regulates splicing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a1b644d0069147debd628820b07cf1c2
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Promoter-proximal pausing mediated by the exon junction complex regulates splicing

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