Small nucleoli are a cellular hallmark of longevity
Animal lifespan is plastic and is regulated by conserved signalling pathways. Here, Tikuet al.show that longevity-enhancing mutations or interventions are associated with reduced nucleolar size in worms, flies, mice and humans, and that nucleolar size can predict life-expectancy in individual worms.
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Nature Portfolio
2017
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oai:doaj.org-article:a1c21506b6f54e62bbf007f51e842a462021-12-02T17:01:24ZSmall nucleoli are a cellular hallmark of longevity10.1038/ncomms160832041-1723https://doaj.org/article/a1c21506b6f54e62bbf007f51e842a462017-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms16083https://doaj.org/toc/2041-1723Animal lifespan is plastic and is regulated by conserved signalling pathways. Here, Tikuet al.show that longevity-enhancing mutations or interventions are associated with reduced nucleolar size in worms, flies, mice and humans, and that nucleolar size can predict life-expectancy in individual worms.Varnesh TikuChirag JainYotam RazShuhei NakamuraBree HeestandWei LiuMartin SpäthH. Eka. D. SuchimanRoman-Ulrich MüllerP. Eline SlagboomLinda PartridgeAdam AntebiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Varnesh Tiku Chirag Jain Yotam Raz Shuhei Nakamura Bree Heestand Wei Liu Martin Späth H. Eka. D. Suchiman Roman-Ulrich Müller P. Eline Slagboom Linda Partridge Adam Antebi Small nucleoli are a cellular hallmark of longevity |
| description |
Animal lifespan is plastic and is regulated by conserved signalling pathways. Here, Tikuet al.show that longevity-enhancing mutations or interventions are associated with reduced nucleolar size in worms, flies, mice and humans, and that nucleolar size can predict life-expectancy in individual worms. |
| format |
article |
| author |
Varnesh Tiku Chirag Jain Yotam Raz Shuhei Nakamura Bree Heestand Wei Liu Martin Späth H. Eka. D. Suchiman Roman-Ulrich Müller P. Eline Slagboom Linda Partridge Adam Antebi |
| author_facet |
Varnesh Tiku Chirag Jain Yotam Raz Shuhei Nakamura Bree Heestand Wei Liu Martin Späth H. Eka. D. Suchiman Roman-Ulrich Müller P. Eline Slagboom Linda Partridge Adam Antebi |
| author_sort |
Varnesh Tiku |
| title |
Small nucleoli are a cellular hallmark of longevity |
| title_short |
Small nucleoli are a cellular hallmark of longevity |
| title_full |
Small nucleoli are a cellular hallmark of longevity |
| title_fullStr |
Small nucleoli are a cellular hallmark of longevity |
| title_full_unstemmed |
Small nucleoli are a cellular hallmark of longevity |
| title_sort |
small nucleoli are a cellular hallmark of longevity |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/a1c21506b6f54e62bbf007f51e842a46 |
| work_keys_str_mv |
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| _version_ |
1718382164965326848 |