SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate host cell pathways to support infection. Here the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
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Nature Portfolio
2021
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oai:doaj.org-article:a210cbf8766241fd8d824076b3b287b52021-12-02T18:02:51ZSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals10.1038/s41467-021-24007-w2041-1723https://doaj.org/article/a210cbf8766241fd8d824076b3b287b52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24007-whttps://doaj.org/toc/2041-1723Viruses manipulate host cell pathways to support infection. Here the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.Nils C. GassenJan PapiesThomas BajajJackson EmanuelFrederik DethloffRobert Lorenz ChuaJakob TrimpertNicolas HeinemannChristine NiemeyerFriderike WeegeKatja HönzkeTom AschmanDaniel E. HeinzKatja WeckmannTim EbertAndreas ZellnerMartina LennarzEmanuel WylerSimon SchroederAnja RichterDaniela NiemeyerKaren HoffmannThomas F. MeyerFrank L. HeppnerVictor M. CormanMarkus LandthalerAndreas C. HockeMarkus MorkelNikolaus OsterriederChristian ConradRoland EilsHelena RadbruchPatrick GiavaliscoChristian DrostenMarcel A. MüllerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Nils C. Gassen Jan Papies Thomas Bajaj Jackson Emanuel Frederik Dethloff Robert Lorenz Chua Jakob Trimpert Nicolas Heinemann Christine Niemeyer Friderike Weege Katja Hönzke Tom Aschman Daniel E. Heinz Katja Weckmann Tim Ebert Andreas Zellner Martina Lennarz Emanuel Wyler Simon Schroeder Anja Richter Daniela Niemeyer Karen Hoffmann Thomas F. Meyer Frank L. Heppner Victor M. Corman Markus Landthaler Andreas C. Hocke Markus Morkel Nikolaus Osterrieder Christian Conrad Roland Eils Helena Radbruch Patrick Giavalisco Christian Drosten Marcel A. Müller SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals |
| description |
Viruses manipulate host cell pathways to support infection. Here the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition. |
| format |
article |
| author |
Nils C. Gassen Jan Papies Thomas Bajaj Jackson Emanuel Frederik Dethloff Robert Lorenz Chua Jakob Trimpert Nicolas Heinemann Christine Niemeyer Friderike Weege Katja Hönzke Tom Aschman Daniel E. Heinz Katja Weckmann Tim Ebert Andreas Zellner Martina Lennarz Emanuel Wyler Simon Schroeder Anja Richter Daniela Niemeyer Karen Hoffmann Thomas F. Meyer Frank L. Heppner Victor M. Corman Markus Landthaler Andreas C. Hocke Markus Morkel Nikolaus Osterrieder Christian Conrad Roland Eils Helena Radbruch Patrick Giavalisco Christian Drosten Marcel A. Müller |
| author_facet |
Nils C. Gassen Jan Papies Thomas Bajaj Jackson Emanuel Frederik Dethloff Robert Lorenz Chua Jakob Trimpert Nicolas Heinemann Christine Niemeyer Friderike Weege Katja Hönzke Tom Aschman Daniel E. Heinz Katja Weckmann Tim Ebert Andreas Zellner Martina Lennarz Emanuel Wyler Simon Schroeder Anja Richter Daniela Niemeyer Karen Hoffmann Thomas F. Meyer Frank L. Heppner Victor M. Corman Markus Landthaler Andreas C. Hocke Markus Morkel Nikolaus Osterrieder Christian Conrad Roland Eils Helena Radbruch Patrick Giavalisco Christian Drosten Marcel A. Müller |
| author_sort |
Nils C. Gassen |
| title |
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals |
| title_short |
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals |
| title_full |
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals |
| title_fullStr |
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals |
| title_full_unstemmed |
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals |
| title_sort |
sars-cov-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a210cbf8766241fd8d824076b3b287b5 |
| work_keys_str_mv |
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| _version_ |
1718378885890965504 |