Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics

During development and pathologies of the central nervous system, blood vessels are closely connected with the innate immune cells, microglia. Here, the authors report that microglia adjust their angiogenic program to shape blood vessels and may depend on tissue stiffness.

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Autores principales: Tejasvi Dudiki, Julia Meller, Gautam Mahajan, Huan Liu, Irina Zhevlakova, Samantha Stefl, Conner Witherow, Eugene Podrez, Chandrasekhar R. Kothapalli, Tatiana V. Byzova
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a21212a9194d4adfb582ac1eb647f6fd
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