Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics

During development and pathologies of the central nervous system, blood vessels are closely connected with the innate immune cells, microglia. Here, the authors report that microglia adjust their angiogenic program to shape blood vessels and may depend on tissue stiffness.

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Autores principales:	Tejasvi Dudiki, Julia Meller, Gautam Mahajan, Huan Liu, Irina Zhevlakova, Samantha Stefl, Conner Witherow, Eugene Podrez, Chandrasekhar R. Kothapalli, Tatiana V. Byzova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a21212a9194d4adfb582ac1eb647f6fd
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spelling	oai:doaj.org-article:a21212a9194d4adfb582ac1eb647f6fd2021-12-02T17:32:12ZMicroglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics10.1038/s41467-020-14787-y2041-1723https://doaj.org/article/a21212a9194d4adfb582ac1eb647f6fd2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14787-yhttps://doaj.org/toc/2041-1723During development and pathologies of the central nervous system, blood vessels are closely connected with the innate immune cells, microglia. Here, the authors report that microglia adjust their angiogenic program to shape blood vessels and may depend on tissue stiffness.Tejasvi DudikiJulia MellerGautam MahajanHuan LiuIrina ZhevlakovaSamantha SteflConner WitherowEugene PodrezChandrasekhar R. KothapalliTatiana V. ByzovaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tejasvi Dudiki Julia Meller Gautam Mahajan Huan Liu Irina Zhevlakova Samantha Stefl Conner Witherow Eugene Podrez Chandrasekhar R. Kothapalli Tatiana V. Byzova Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics
description	During development and pathologies of the central nervous system, blood vessels are closely connected with the innate immune cells, microglia. Here, the authors report that microglia adjust their angiogenic program to shape blood vessels and may depend on tissue stiffness.
format	article
author	Tejasvi Dudiki Julia Meller Gautam Mahajan Huan Liu Irina Zhevlakova Samantha Stefl Conner Witherow Eugene Podrez Chandrasekhar R. Kothapalli Tatiana V. Byzova
author_facet	Tejasvi Dudiki Julia Meller Gautam Mahajan Huan Liu Irina Zhevlakova Samantha Stefl Conner Witherow Eugene Podrez Chandrasekhar R. Kothapalli Tatiana V. Byzova
author_sort	Tejasvi Dudiki
title	Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics
title_short	Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics
title_full	Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics
title_fullStr	Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics
title_full_unstemmed	Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics
title_sort	microglia control vascular architecture via a tgfβ1 dependent paracrine mechanism linked to tissue mechanics
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a21212a9194d4adfb582ac1eb647f6fd
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Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics

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