Single-cell RNA sequencing to characterize the response of pancreatic cancer to anti-PD-1 immunotherapy

Single-cell RNA sequencing to characterize the response of pancreatic cancer to anti-PD-1 immunotherapy

Pancreatic cancer (PaC) is resistant to immune checkpoint therapy, but the underlying mechanisms are largely unknown. In this study, we have established four orthotopic PaC murine models with different PaC cell lines by intra-pancreatic inoculation. Therapeutic examinations demonstrate that only tum...

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Bibliographic Details
Main Authors: Jing Zhou, Yuexu Jiang, Yue Huang, Qiongling Wang, Jussuf T. Kaifi, Eric T. Kimchi, Chiswili Yves Chabu, Zhenguo Liu, Trupti Joshi, Guangfu Li
Format: article
Language:EN
Published: Elsevier 2022
Subjects:
Pancreatic cancer (PaC)
Single-cell sequencing (scRNA-seq)
Programmed cell death protein 1 (PD-1)
αPD-1 antibody (αPD-1 Ab)
Tumor-associated macrophages (TAM)
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/a21934920a644ea9857ba22b86db5b6e
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https://doaj.org/article/a21934920a644ea9857ba22b86db5b6e

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