NSC828779 Alleviates Renal Tubulointerstitial Lesions Involving Interleukin-36 Signaling in Mice

NSC828779 Alleviates Renal Tubulointerstitial Lesions Involving Interleukin-36 Signaling in Mice

Renal tubulointerstitial lesions (TILs), a common pathologic hallmark of chronic kidney disease that evolves to end-stage renal disease, is characterized by progressive inflammation and pronounced fibrosis of the kidney. However, current therapeutic approaches to treat these lesions remain largely i...

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Auteurs principaux: Shin-Ruen Yang, Szu-Chun Hung, Lichieh Julie Chu, Kuo-Feng Hua, Chyou-Wei Wei, I-Lin Tsai, Chih-Chin Kao, Chih-Chien Sung, Pauling Chu, Chung-Yao Wu, Ann Chen, Alexander T. H. Wu, Feng-Cheng Liu, Hsu-Shan Huang, Shuk-Man Ka
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
salicylanilide derivative
tubulointerstitial lesions
IL-36α
mechanically induced constant pressure
IL-36α/NLRP3 inflammasome
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/a2306ac572bc4bf5b23db0435511be33
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https://doaj.org/article/a2306ac572bc4bf5b23db0435511be33

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