Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.

Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.

In the present study, we analyzed the functional profile of CD8+ T-cell responses directed against autologous transmitted/founder HIV-1 isolates during acute and early infection, and examined whether multifunctionality is required for selection of virus escape mutations. Seven anti-retroviral therap...

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Bibliographic Details
Main Authors: Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K P Liu, Emma L Turnbull, Jesus F Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D Tomaras, Barton F Haynes, Clive M Gray, Persephone Borrow, Mario Roederer, Andrew J McMichael, Kent J Weinhold
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/a23efb6b873d445da5c85d22e3a5462f
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