Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis

In bacteria, the conserved trans-translation system serves as the primary pathway of ribosome rescue, but many species can also use alternative rescue pathways. Here the authors report that in B. subtilis, the rescue factor BrfA binds to non-stop stalled ribosomes, recruits RF2 but not RF1, and indu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Naomi Shimokawa-Chiba, Claudia Müller, Keigo Fujiwara, Bertrand Beckert, Koreaki Ito, Daniel N. Wilson, Shinobu Chiba
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2679a073e3943e994ac5d75350e424f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a2679a073e3943e994ac5d75350e424f
record_format	dspace
spelling	oai:doaj.org-article:a2679a073e3943e994ac5d75350e424f2021-12-02T14:39:20ZRelease factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis10.1038/s41467-019-13408-72041-1723https://doaj.org/article/a2679a073e3943e994ac5d75350e424f2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13408-7https://doaj.org/toc/2041-1723In bacteria, the conserved trans-translation system serves as the primary pathway of ribosome rescue, but many species can also use alternative rescue pathways. Here the authors report that in B. subtilis, the rescue factor BrfA binds to non-stop stalled ribosomes, recruits RF2 but not RF1, and induces transition of the ribosome into an open active conformation.Naomi Shimokawa-ChibaClaudia MüllerKeigo FujiwaraBertrand BeckertKoreaki ItoDaniel N. WilsonShinobu ChibaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naomi Shimokawa-Chiba Claudia Müller Keigo Fujiwara Bertrand Beckert Koreaki Ito Daniel N. Wilson Shinobu Chiba Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis
description	In bacteria, the conserved trans-translation system serves as the primary pathway of ribosome rescue, but many species can also use alternative rescue pathways. Here the authors report that in B. subtilis, the rescue factor BrfA binds to non-stop stalled ribosomes, recruits RF2 but not RF1, and induces transition of the ribosome into an open active conformation.
format	article
author	Naomi Shimokawa-Chiba Claudia Müller Keigo Fujiwara Bertrand Beckert Koreaki Ito Daniel N. Wilson Shinobu Chiba
author_facet	Naomi Shimokawa-Chiba Claudia Müller Keigo Fujiwara Bertrand Beckert Koreaki Ito Daniel N. Wilson Shinobu Chiba
author_sort	Naomi Shimokawa-Chiba
title	Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis
title_short	Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis
title_full	Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis
title_fullStr	Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis
title_full_unstemmed	Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis
title_sort	release factor-dependent ribosome rescue by brfa in the gram-positive bacterium bacillus subtilis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a2679a073e3943e994ac5d75350e424f
work_keys_str_mv	AT naomishimokawachiba releasefactordependentribosomerescuebybrfainthegrampositivebacteriumbacillussubtilis AT claudiamuller releasefactordependentribosomerescuebybrfainthegrampositivebacteriumbacillussubtilis AT keigofujiwara releasefactordependentribosomerescuebybrfainthegrampositivebacteriumbacillussubtilis AT bertrandbeckert releasefactordependentribosomerescuebybrfainthegrampositivebacteriumbacillussubtilis AT koreakiito releasefactordependentribosomerescuebybrfainthegrampositivebacteriumbacillussubtilis AT danielnwilson releasefactordependentribosomerescuebybrfainthegrampositivebacteriumbacillussubtilis AT shinobuchiba releasefactordependentribosomerescuebybrfainthegrampositivebacteriumbacillussubtilis
_version_	1718390672299393024

Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis

Ejemplares similares