Antimalarial drug quality in the most severely malarious parts of Africa - a six country study.

A range of antimalarial drugs were procured from private pharmacies in urban and peri-urban areas in the major cities of six African countries, situated in the part of that continent and the world that is most highly endemic for malaria. Semi-quantitative thin-layer chromatography (TLC) and dissolut...

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Main Authors:	Roger Bate, Philip Coticelli, Richard Tren, Amir Attaran
Format:	article
Language:	EN
Published:	Public Library of Science (PLoS) 2008
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/a2747fc8b10c41e9b69fbd0863a4d567
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spelling	oai:doaj.org-article:a2747fc8b10c41e9b69fbd0863a4d5672021-11-25T06:12:37ZAntimalarial drug quality in the most severely malarious parts of Africa - a six country study.1932-620310.1371/journal.pone.0002132https://doaj.org/article/a2747fc8b10c41e9b69fbd0863a4d5672008-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18461128/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203A range of antimalarial drugs were procured from private pharmacies in urban and peri-urban areas in the major cities of six African countries, situated in the part of that continent and the world that is most highly endemic for malaria. Semi-quantitative thin-layer chromatography (TLC) and dissolution testing were used to measure active pharmaceutical ingredient content against internationally acceptable standards. 35% of all samples tested failed either or both tests, and were substandard. Further, 33% of treatments collected were artemisinin monotherapies, most of which (78%) were manufactured in disobservance of an appeal by the World Health Organisation (WHO) to withdraw these clinically inappropriate medicines from the market. The high persistence of substandard drugs and clinically inappropriate artemisinin monotherapies in the private sector risks patient safety and, through drug resistance, places the future of malaria treatment at risk globally.Roger BatePhilip CoticelliRichard TrenAmir AttaranPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 5, p e2132 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roger Bate Philip Coticelli Richard Tren Amir Attaran Antimalarial drug quality in the most severely malarious parts of Africa - a six country study.
description	A range of antimalarial drugs were procured from private pharmacies in urban and peri-urban areas in the major cities of six African countries, situated in the part of that continent and the world that is most highly endemic for malaria. Semi-quantitative thin-layer chromatography (TLC) and dissolution testing were used to measure active pharmaceutical ingredient content against internationally acceptable standards. 35% of all samples tested failed either or both tests, and were substandard. Further, 33% of treatments collected were artemisinin monotherapies, most of which (78%) were manufactured in disobservance of an appeal by the World Health Organisation (WHO) to withdraw these clinically inappropriate medicines from the market. The high persistence of substandard drugs and clinically inappropriate artemisinin monotherapies in the private sector risks patient safety and, through drug resistance, places the future of malaria treatment at risk globally.
format	article
author	Roger Bate Philip Coticelli Richard Tren Amir Attaran
author_facet	Roger Bate Philip Coticelli Richard Tren Amir Attaran
author_sort	Roger Bate
title	Antimalarial drug quality in the most severely malarious parts of Africa - a six country study.
title_short	Antimalarial drug quality in the most severely malarious parts of Africa - a six country study.
title_full	Antimalarial drug quality in the most severely malarious parts of Africa - a six country study.
title_fullStr	Antimalarial drug quality in the most severely malarious parts of Africa - a six country study.
title_full_unstemmed	Antimalarial drug quality in the most severely malarious parts of Africa - a six country study.
title_sort	antimalarial drug quality in the most severely malarious parts of africa - a six country study.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/a2747fc8b10c41e9b69fbd0863a4d567
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Antimalarial drug quality in the most severely malarious parts of Africa - a six country study.

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