A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation

Inflammatory diseases of the pancreas are currently untreatable and lack a pre-clinical model that recapitulates the hallmarks of the human pathology. Here, the authors generate a knock-in mouse strain with increased tripsinogen autoactivation and show that it develops spontaneous pancreatic patholo...

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Autores principales:	Andrea Geisz, Miklós Sahin-Tóth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2962e90a2a946a288e473df4b9941c0
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spelling	oai:doaj.org-article:a2962e90a2a946a288e473df4b9941c02021-12-02T14:40:54ZA preclinical model of chronic pancreatitis driven by trypsinogen autoactivation10.1038/s41467-018-07347-y2041-1723https://doaj.org/article/a2962e90a2a946a288e473df4b9941c02018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07347-yhttps://doaj.org/toc/2041-1723Inflammatory diseases of the pancreas are currently untreatable and lack a pre-clinical model that recapitulates the hallmarks of the human pathology. Here, the authors generate a knock-in mouse strain with increased tripsinogen autoactivation and show that it develops spontaneous pancreatic pathology with some key features of human pancreatitis.Andrea GeiszMiklós Sahin-TóthNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrea Geisz Miklós Sahin-Tóth A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation
description	Inflammatory diseases of the pancreas are currently untreatable and lack a pre-clinical model that recapitulates the hallmarks of the human pathology. Here, the authors generate a knock-in mouse strain with increased tripsinogen autoactivation and show that it develops spontaneous pancreatic pathology with some key features of human pancreatitis.
format	article
author	Andrea Geisz Miklós Sahin-Tóth
author_facet	Andrea Geisz Miklós Sahin-Tóth
author_sort	Andrea Geisz
title	A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation
title_short	A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation
title_full	A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation
title_fullStr	A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation
title_full_unstemmed	A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation
title_sort	preclinical model of chronic pancreatitis driven by trypsinogen autoactivation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a2962e90a2a946a288e473df4b9941c0
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A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation

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