Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation

The transcription factor, serum response factor, SRF regulates critical smooth muscle (SM) contractile gene expression but what else controls SM differentiation is unclear. Here, Horita et al. demonstrate that nuclear PTEN acts with SRF at the transcriptional level to maintain the differentiated SM...

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Autores principales:	Henrick Horita, Christina L. Wysoczynski, Lori A. Walker, Karen S. Moulton, Marcella Li, Allison Ostriker, Rebecca Tucker, Timothy A. McKinsey, Mair E. A. Churchill, Raphael A. Nemenoff, Mary C. M. Weiser-Evans
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2a037feef7f4c279013ebdd96c7d09b
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spelling	oai:doaj.org-article:a2a037feef7f4c279013ebdd96c7d09b2021-12-02T14:38:33ZNuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation10.1038/ncomms108302041-1723https://doaj.org/article/a2a037feef7f4c279013ebdd96c7d09b2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10830https://doaj.org/toc/2041-1723The transcription factor, serum response factor, SRF regulates critical smooth muscle (SM) contractile gene expression but what else controls SM differentiation is unclear. Here, Horita et al. demonstrate that nuclear PTEN acts with SRF at the transcriptional level to maintain the differentiated SM phenotype.Henrick HoritaChristina L. WysoczynskiLori A. WalkerKaren S. MoultonMarcella LiAllison OstrikerRebecca TuckerTimothy A. McKinseyMair E. A. ChurchillRaphael A. NemenoffMary C. M. Weiser-EvansNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Henrick Horita Christina L. Wysoczynski Lori A. Walker Karen S. Moulton Marcella Li Allison Ostriker Rebecca Tucker Timothy A. McKinsey Mair E. A. Churchill Raphael A. Nemenoff Mary C. M. Weiser-Evans Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation
description	The transcription factor, serum response factor, SRF regulates critical smooth muscle (SM) contractile gene expression but what else controls SM differentiation is unclear. Here, Horita et al. demonstrate that nuclear PTEN acts with SRF at the transcriptional level to maintain the differentiated SM phenotype.
format	article
author	Henrick Horita Christina L. Wysoczynski Lori A. Walker Karen S. Moulton Marcella Li Allison Ostriker Rebecca Tucker Timothy A. McKinsey Mair E. A. Churchill Raphael A. Nemenoff Mary C. M. Weiser-Evans
author_facet	Henrick Horita Christina L. Wysoczynski Lori A. Walker Karen S. Moulton Marcella Li Allison Ostriker Rebecca Tucker Timothy A. McKinsey Mair E. A. Churchill Raphael A. Nemenoff Mary C. M. Weiser-Evans
author_sort	Henrick Horita
title	Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation
title_short	Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation
title_full	Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation
title_fullStr	Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation
title_full_unstemmed	Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation
title_sort	nuclear pten functions as an essential regulator of srf-dependent transcription to control smooth muscle differentiation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a2a037feef7f4c279013ebdd96c7d09b
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Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation

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