Designing minimal genomes using whole-cell models

Genome engineering will one day benefit from computational tools that can design genomes with desired functions. Here the authors develop computational design-simulate-test algorithms to design minimal genomes based on the whole-cell model of Mycoplasma genitalium.

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Autores principales:	Joshua Rees-Garbutt, Oliver Chalkley, Sophie Landon, Oliver Purcell, Lucia Marucci, Claire Grierson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2d27e6f513347d0a606d457b9efaf7f
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id	oai:doaj.org-article:a2d27e6f513347d0a606d457b9efaf7f
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spelling	oai:doaj.org-article:a2d27e6f513347d0a606d457b9efaf7f2021-12-02T14:42:50ZDesigning minimal genomes using whole-cell models10.1038/s41467-020-14545-02041-1723https://doaj.org/article/a2d27e6f513347d0a606d457b9efaf7f2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14545-0https://doaj.org/toc/2041-1723Genome engineering will one day benefit from computational tools that can design genomes with desired functions. Here the authors develop computational design-simulate-test algorithms to design minimal genomes based on the whole-cell model of Mycoplasma genitalium.Joshua Rees-GarbuttOliver ChalkleySophie LandonOliver PurcellLucia MarucciClaire GriersonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua Rees-Garbutt Oliver Chalkley Sophie Landon Oliver Purcell Lucia Marucci Claire Grierson Designing minimal genomes using whole-cell models
description	Genome engineering will one day benefit from computational tools that can design genomes with desired functions. Here the authors develop computational design-simulate-test algorithms to design minimal genomes based on the whole-cell model of Mycoplasma genitalium.
format	article
author	Joshua Rees-Garbutt Oliver Chalkley Sophie Landon Oliver Purcell Lucia Marucci Claire Grierson
author_facet	Joshua Rees-Garbutt Oliver Chalkley Sophie Landon Oliver Purcell Lucia Marucci Claire Grierson
author_sort	Joshua Rees-Garbutt
title	Designing minimal genomes using whole-cell models
title_short	Designing minimal genomes using whole-cell models
title_full	Designing minimal genomes using whole-cell models
title_fullStr	Designing minimal genomes using whole-cell models
title_full_unstemmed	Designing minimal genomes using whole-cell models
title_sort	designing minimal genomes using whole-cell models
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a2d27e6f513347d0a606d457b9efaf7f
work_keys_str_mv	AT joshuareesgarbutt designingminimalgenomesusingwholecellmodels AT oliverchalkley designingminimalgenomesusingwholecellmodels AT sophielandon designingminimalgenomesusingwholecellmodels AT oliverpurcell designingminimalgenomesusingwholecellmodels AT luciamarucci designingminimalgenomesusingwholecellmodels AT clairegrierson designingminimalgenomesusingwholecellmodels
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Designing minimal genomes using whole-cell models

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