Computational design of binding proteins to EGFR domain II.

Computational design of binding proteins to EGFR domain II.

We developed a process to produce novel interactions between two previously unrelated proteins. This process selects protein scaffolds and designs protein interfaces that bind to a surface patch of interest on a target protein. Scaffolds with shapes complementary to the target surface patch were scr...

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Auteurs principaux: Yoon Sup Choi, Soomin Yoon, Kyung-Lock Kim, Jiho Yoo, Parkyong Song, Minsoo Kim, Young-Eun Shin, Won Jun Yang, Jung-eun Noh, Hyun-Soo Cho, Sanguk Kim, Junho Chung, Sung Ho Ryu
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/a2d3722fb48247248b0db2e254f5bea7
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https://doaj.org/article/a2d3722fb48247248b0db2e254f5bea7

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