A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells

Abstract Phagocytosis of microbial pathogens, dying or dead cells, and cell debris is essential to maintain tissue homeostasis. Impairment of these processes is associated with autoimmunity, developmental defects and toxic protein accumulation. However, the underlying molecular mechanisms of phagocy...

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Autores principales: Benjamin Lindner, Eva Martin, Monika Steininger, Aleksandra Bundalo, Martin Lenter, Johannes Zuber, Michael Schuler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a2d507b2b5d447639ff1bed120983bd7
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