Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation

Signalling through the endothelin receptor ETB, a class A GPCR, induces nitric oxide-mediated vasorelaxation. Here the authors present the crystal structures of the human ETB receptor bound to the peptide hormone endothelin-3 and in complex with the ETB-selective partial agonist IRL1620 and discuss...

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Autores principales:	Wataru Shihoya, Tamaki Izume, Asuka Inoue, Keitaro Yamashita, Francois Marie Ngako Kadji, Kunio Hirata, Junken Aoki, Tomohiro Nishizawa, Osamu Nureki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2d527b16f98446e9ee5dcdca8a86e97
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spelling	oai:doaj.org-article:a2d527b16f98446e9ee5dcdca8a86e972021-12-02T16:50:06ZCrystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation10.1038/s41467-018-07094-02041-1723https://doaj.org/article/a2d527b16f98446e9ee5dcdca8a86e972018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07094-0https://doaj.org/toc/2041-1723Signalling through the endothelin receptor ETB, a class A GPCR, induces nitric oxide-mediated vasorelaxation. Here the authors present the crystal structures of the human ETB receptor bound to the peptide hormone endothelin-3 and in complex with the ETB-selective partial agonist IRL1620 and discuss mechanistic implications for receptor activation.Wataru ShihoyaTamaki IzumeAsuka InoueKeitaro YamashitaFrancois Marie Ngako KadjiKunio HirataJunken AokiTomohiro NishizawaOsamu NurekiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wataru Shihoya Tamaki Izume Asuka Inoue Keitaro Yamashita Francois Marie Ngako Kadji Kunio Hirata Junken Aoki Tomohiro Nishizawa Osamu Nureki Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation
description	Signalling through the endothelin receptor ETB, a class A GPCR, induces nitric oxide-mediated vasorelaxation. Here the authors present the crystal structures of the human ETB receptor bound to the peptide hormone endothelin-3 and in complex with the ETB-selective partial agonist IRL1620 and discuss mechanistic implications for receptor activation.
format	article
author	Wataru Shihoya Tamaki Izume Asuka Inoue Keitaro Yamashita Francois Marie Ngako Kadji Kunio Hirata Junken Aoki Tomohiro Nishizawa Osamu Nureki
author_facet	Wataru Shihoya Tamaki Izume Asuka Inoue Keitaro Yamashita Francois Marie Ngako Kadji Kunio Hirata Junken Aoki Tomohiro Nishizawa Osamu Nureki
author_sort	Wataru Shihoya
title	Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation
title_short	Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation
title_full	Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation
title_fullStr	Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation
title_full_unstemmed	Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation
title_sort	crystal structures of human etb receptor provide mechanistic insight into receptor activation and partial activation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a2d527b16f98446e9ee5dcdca8a86e97
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_version_	1718383117066043392

Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation

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