Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

The molecular mechanisms regulating skin dermal changes are unclear. Here, the authors show that deletion of Hedgehog (Hh) in the upper dermis alters the response to epidermal Wnt signalling, which, together with changes in extracellular matrix production, influences distinct fibroblast lineages dif...

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Autores principales:	Beate M. Lichtenberger, Maria Mastrogiannaki, Fiona M. Watt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2f00ef4034b4d2ea03277e5251ed944
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spelling	oai:doaj.org-article:a2f00ef4034b4d2ea03277e5251ed9442021-12-02T17:33:08ZEpidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages10.1038/ncomms105372041-1723https://doaj.org/article/a2f00ef4034b4d2ea03277e5251ed9442016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10537https://doaj.org/toc/2041-1723The molecular mechanisms regulating skin dermal changes are unclear. Here, the authors show that deletion of Hedgehog (Hh) in the upper dermis alters the response to epidermal Wnt signalling, which, together with changes in extracellular matrix production, influences distinct fibroblast lineages differently.Beate M. LichtenbergerMaria MastrogiannakiFiona M. WattNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Beate M. Lichtenberger Maria Mastrogiannaki Fiona M. Watt Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages
description	The molecular mechanisms regulating skin dermal changes are unclear. Here, the authors show that deletion of Hedgehog (Hh) in the upper dermis alters the response to epidermal Wnt signalling, which, together with changes in extracellular matrix production, influences distinct fibroblast lineages differently.
format	article
author	Beate M. Lichtenberger Maria Mastrogiannaki Fiona M. Watt
author_facet	Beate M. Lichtenberger Maria Mastrogiannaki Fiona M. Watt
author_sort	Beate M. Lichtenberger
title	Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages
title_short	Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages
title_full	Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages
title_fullStr	Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages
title_full_unstemmed	Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages
title_sort	epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a2f00ef4034b4d2ea03277e5251ed944
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Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

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