The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate

Jing Zhang,1,* Yingchong Chen,1,* Xiang Li,1,2 Xinli Liang,1 Xiaojian Luo2 1Key Laboratory of Modern Preparation of TCM, Ministry of Education, 2State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine,...

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Main Authors:	Zhang J, Chen YC, Li X, Liang XL, Luo XJ
Format:	article
Language:	EN
Published:	Dove Medical Press 2016
Subjects:	vincristine sulfate long-circulating materials zeta potential stability pharmacokinetics Medicine (General) R5-920
Online Access:	https://doaj.org/article/a2fc29dee5e94de2822294f999fcfbac
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spelling	oai:doaj.org-article:a2fc29dee5e94de2822294f999fcfbac2021-12-02T00:46:37ZThe influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate1178-2013https://doaj.org/article/a2fc29dee5e94de2822294f999fcfbac2016-08-01T00:00:00Zhttps://www.dovepress.com/the-influence-of-different-long-circulating-materials-on-the-pharmacok-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jing Zhang,1,* Yingchong Chen,1,* Xiang Li,1,2 Xinli Liang,1 Xiaojian Luo2 1Key Laboratory of Modern Preparation of TCM, Ministry of Education, 2State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang, People’s Republic of China *These authors contributed equally to this work Purpose: This study was designed to improve the in vivo pharmacokinetics of long-circulating vincristine sulfate (VS)-loaded liposomes; three different long-circulating materials, chitosan, poly(ethylene glycol)-1,2-distearoyl sn-glycero-3-phosphatidylethanolamine (PEG-DSPE), and poly(ethylene glycol)-poly-lactide-co-glycolide (PEG-PLGA), were evaluated at the same coating molar ratio with the commercial product Marqibo® (vincristine sulfate liposome injection [VSLI]). Materials and methods: VS-loaded liposomes were prepared by a pH gradient method and were then coated with chitosan, PEG-DSPE, or PEG-PLGA. Physicochemical properties, including the morphology, particle size, zeta potential, encapsulation efficiency (EE%), pH, drug loading, and in vitro release, were determined. Preservation stability and pharmacokinetic studies were performed to compare the membrane-coated liposomes with either commercially available liposomes or the VS solution. Results: The sphere-like morphology of the vesicles was confirmed by transmission electron microscope. Increased particle size, especially for the chitosan formulation, was observed after the coating process. However, the EE% was ~99.0% with drug loading at 2.0 mg/mL, which did not change after the coating process. The coating of long-circulation materials, except for chitosan, resulted in negatively charged and stable vesicles at physiological pH. The near-zero zeta potential exhibited by the PEG-DSPE formulation leads to a longer circulation lifetime and improved absorption for VS, when compared with the PEG-PLGA formulation. Compared with the commercial product, PEG was responsible for a higher plasma VS concentration and a longer half-life. Conclusion: PEG-DSPE coating may be related to better absorption, based on the stability and a pharmacokinetic improvement in the blood circulation time. Keywords: vincristine sulfate, long-circulating materials, zeta potential, stability, pharmacokineticsZhang JChen YCLi XLiang XLLuo XJDove Medical Pressarticlevincristine sulfatelong-circulating materialszeta potentialstabilitypharmacokineticsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4187-4197 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	vincristine sulfate long-circulating materials zeta potential stability pharmacokinetics Medicine (General) R5-920
spellingShingle	vincristine sulfate long-circulating materials zeta potential stability pharmacokinetics Medicine (General) R5-920 Zhang J Chen YC Li X Liang XL Luo XJ The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate
description	Jing Zhang,1,* Yingchong Chen,1,* Xiang Li,1,2 Xinli Liang,1 Xiaojian Luo2 1Key Laboratory of Modern Preparation of TCM, Ministry of Education, 2State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang, People’s Republic of China *These authors contributed equally to this work Purpose: This study was designed to improve the in vivo pharmacokinetics of long-circulating vincristine sulfate (VS)-loaded liposomes; three different long-circulating materials, chitosan, poly(ethylene glycol)-1,2-distearoyl sn-glycero-3-phosphatidylethanolamine (PEG-DSPE), and poly(ethylene glycol)-poly-lactide-co-glycolide (PEG-PLGA), were evaluated at the same coating molar ratio with the commercial product Marqibo® (vincristine sulfate liposome injection [VSLI]). Materials and methods: VS-loaded liposomes were prepared by a pH gradient method and were then coated with chitosan, PEG-DSPE, or PEG-PLGA. Physicochemical properties, including the morphology, particle size, zeta potential, encapsulation efficiency (EE%), pH, drug loading, and in vitro release, were determined. Preservation stability and pharmacokinetic studies were performed to compare the membrane-coated liposomes with either commercially available liposomes or the VS solution. Results: The sphere-like morphology of the vesicles was confirmed by transmission electron microscope. Increased particle size, especially for the chitosan formulation, was observed after the coating process. However, the EE% was ~99.0% with drug loading at 2.0 mg/mL, which did not change after the coating process. The coating of long-circulation materials, except for chitosan, resulted in negatively charged and stable vesicles at physiological pH. The near-zero zeta potential exhibited by the PEG-DSPE formulation leads to a longer circulation lifetime and improved absorption for VS, when compared with the PEG-PLGA formulation. Compared with the commercial product, PEG was responsible for a higher plasma VS concentration and a longer half-life. Conclusion: PEG-DSPE coating may be related to better absorption, based on the stability and a pharmacokinetic improvement in the blood circulation time. Keywords: vincristine sulfate, long-circulating materials, zeta potential, stability, pharmacokinetics
format	article
author	Zhang J Chen YC Li X Liang XL Luo XJ
author_facet	Zhang J Chen YC Li X Liang XL Luo XJ
author_sort	Zhang J
title	The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate
title_short	The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate
title_full	The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate
title_fullStr	The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate
title_full_unstemmed	The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate
title_sort	influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/a2fc29dee5e94de2822294f999fcfbac
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The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate

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