A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function

Jeremy To et al. develop an ultra-high-content assay platform used to interrogate T-cell-mediated killing of 3D multicellular tumor spheroids. They screen 1,800 annotated compounds to identify small molecules that enhance cytotoxic CD8+ T-cell activity in an antigen-dependent manner, demonstrating t...

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Autores principales: Jeremy To, Doug Quackenbush, Emily Rowell, Lilin Li, Connor Reed, Frederick Lo, Shane R. Horman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a2fe4f359c6846cb9abcd2c93d669558
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