A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function

Jeremy To et al. develop an ultra-high-content assay platform used to interrogate T-cell-mediated killing of 3D multicellular tumor spheroids. They screen 1,800 annotated compounds to identify small molecules that enhance cytotoxic CD8+ T-cell activity in an antigen-dependent manner, demonstrating t...

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Autores principales:	Jeremy To, Doug Quackenbush, Emily Rowell, Lilin Li, Connor Reed, Frederick Lo, Shane R. Horman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a2fe4f359c6846cb9abcd2c93d669558
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spelling	oai:doaj.org-article:a2fe4f359c6846cb9abcd2c93d6695582021-12-02T11:56:22ZA biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function10.1038/s42003-020-01565-12399-3642https://doaj.org/article/a2fe4f359c6846cb9abcd2c93d6695582021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01565-1https://doaj.org/toc/2399-3642Jeremy To et al. develop an ultra-high-content assay platform used to interrogate T-cell-mediated killing of 3D multicellular tumor spheroids. They screen 1,800 annotated compounds to identify small molecules that enhance cytotoxic CD8+ T-cell activity in an antigen-dependent manner, demonstrating the utility of this assay platform.Jeremy ToDoug QuackenbushEmily RowellLilin LiConnor ReedFrederick LoShane R. HormanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jeremy To Doug Quackenbush Emily Rowell Lilin Li Connor Reed Frederick Lo Shane R. Horman A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function
description	Jeremy To et al. develop an ultra-high-content assay platform used to interrogate T-cell-mediated killing of 3D multicellular tumor spheroids. They screen 1,800 annotated compounds to identify small molecules that enhance cytotoxic CD8+ T-cell activity in an antigen-dependent manner, demonstrating the utility of this assay platform.
format	article
author	Jeremy To Doug Quackenbush Emily Rowell Lilin Li Connor Reed Frederick Lo Shane R. Horman
author_facet	Jeremy To Doug Quackenbush Emily Rowell Lilin Li Connor Reed Frederick Lo Shane R. Horman
author_sort	Jeremy To
title	A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function
title_short	A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function
title_full	A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function
title_fullStr	A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function
title_full_unstemmed	A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function
title_sort	biomimetic assay platform for the interrogation of antigen-dependent anti-tumor t-cell function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a2fe4f359c6846cb9abcd2c93d669558
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A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function

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