Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle

Recent data suggest that muscle contraction is regulated by thick filament mechano-sensing in addition to the well-known thin filament-mediated calcium signalling pathway. Here the authors provide direct evidence that myosin activation in skeletal muscle is controlled by thick filament stress indepe...

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Auteurs principaux:	L. Fusi, E. Brunello, Z. Yan, M. Irving
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/a33d9371f6e84246a2c0cb6421e371e0
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spelling	oai:doaj.org-article:a33d9371f6e84246a2c0cb6421e371e02021-12-02T14:39:54ZThick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle10.1038/ncomms132812041-1723https://doaj.org/article/a33d9371f6e84246a2c0cb6421e371e02016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13281https://doaj.org/toc/2041-1723Recent data suggest that muscle contraction is regulated by thick filament mechano-sensing in addition to the well-known thin filament-mediated calcium signalling pathway. Here the authors provide direct evidence that myosin activation in skeletal muscle is controlled by thick filament stress independently of calcium.L. FusiE. BrunelloZ. YanM. IrvingNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q L. Fusi E. Brunello Z. Yan M. Irving Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
description	Recent data suggest that muscle contraction is regulated by thick filament mechano-sensing in addition to the well-known thin filament-mediated calcium signalling pathway. Here the authors provide direct evidence that myosin activation in skeletal muscle is controlled by thick filament stress independently of calcium.
format	article
author	L. Fusi E. Brunello Z. Yan M. Irving
author_facet	L. Fusi E. Brunello Z. Yan M. Irving
author_sort	L. Fusi
title	Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
title_short	Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
title_full	Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
title_fullStr	Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
title_full_unstemmed	Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
title_sort	thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a33d9371f6e84246a2c0cb6421e371e0
work_keys_str_mv	AT lfusi thickfilamentmechanosensingisacalciumindependentregulatorymechanisminskeletalmuscle AT ebrunello thickfilamentmechanosensingisacalciumindependentregulatorymechanisminskeletalmuscle AT zyan thickfilamentmechanosensingisacalciumindependentregulatorymechanisminskeletalmuscle AT mirving thickfilamentmechanosensingisacalciumindependentregulatorymechanisminskeletalmuscle
_version_	1718390491333001216

Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle

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