Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications
Duplication of chromosome 15q11-q13 is associated with autism spectrum disorder (ASD). Here, the authors show that in mice paternal Dup15q results in ASD-like neuronal and behavioural impairment driven by Necdin.
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Main Authors: | Kota Tamada, Keita Fukumoto, Tsuyoshi Toya, Nobuhiro Nakai, Janak R. Awasthi, Shinji Tanaka, Shigeo Okabe, François Spitz, Fumihito Saitow, Hidenori Suzuki, Toru Takumi |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
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Online Access: | https://doaj.org/article/a34621df8ce54a06a59e939a043096f2 |
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