Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies

Patients with myotonic dystrophy need to undergo invasive muscle biopsies to monitor disease progression and response to therapy. Here, the authors show that extracellular RNAs in human urine can be used as biomarkers to differentiate patients from unaffected controls, and to monitor exon skipping i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Layal Antoury, Ningyan Hu, Leonora Balaj, Sudeshna Das, Sofia Georghiou, Basil Darras, Tim Clark, Xandra O. Breakefield, Thurman M. Wheeler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a34cd40d232146518807809a9a2dd9f6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a34cd40d232146518807809a9a2dd9f6
record_format	dspace
spelling	oai:doaj.org-article:a34cd40d232146518807809a9a2dd9f62021-12-02T14:40:09ZAnalysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies10.1038/s41467-018-06206-02041-1723https://doaj.org/article/a34cd40d232146518807809a9a2dd9f62018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06206-0https://doaj.org/toc/2041-1723Patients with myotonic dystrophy need to undergo invasive muscle biopsies to monitor disease progression and response to therapy. Here, the authors show that extracellular RNAs in human urine can be used as biomarkers to differentiate patients from unaffected controls, and to monitor exon skipping in patients with Duchenne muscular dystrophy taking the drug eteplirsen.Layal AntouryNingyan HuLeonora BalajSudeshna DasSofia GeorghiouBasil DarrasTim ClarkXandra O. BreakefieldThurman M. WheelerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Layal Antoury Ningyan Hu Leonora Balaj Sudeshna Das Sofia Georghiou Basil Darras Tim Clark Xandra O. Breakefield Thurman M. Wheeler Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies
description	Patients with myotonic dystrophy need to undergo invasive muscle biopsies to monitor disease progression and response to therapy. Here, the authors show that extracellular RNAs in human urine can be used as biomarkers to differentiate patients from unaffected controls, and to monitor exon skipping in patients with Duchenne muscular dystrophy taking the drug eteplirsen.
format	article
author	Layal Antoury Ningyan Hu Leonora Balaj Sudeshna Das Sofia Georghiou Basil Darras Tim Clark Xandra O. Breakefield Thurman M. Wheeler
author_facet	Layal Antoury Ningyan Hu Leonora Balaj Sudeshna Das Sofia Georghiou Basil Darras Tim Clark Xandra O. Breakefield Thurman M. Wheeler
author_sort	Layal Antoury
title	Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies
title_short	Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies
title_full	Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies
title_fullStr	Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies
title_full_unstemmed	Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies
title_sort	analysis of extracellular mrna in human urine reveals splice variant biomarkers of muscular dystrophies
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a34cd40d232146518807809a9a2dd9f6
work_keys_str_mv	AT layalantoury analysisofextracellularmrnainhumanurinerevealssplicevariantbiomarkersofmusculardystrophies AT ningyanhu analysisofextracellularmrnainhumanurinerevealssplicevariantbiomarkersofmusculardystrophies AT leonorabalaj analysisofextracellularmrnainhumanurinerevealssplicevariantbiomarkersofmusculardystrophies AT sudeshnadas analysisofextracellularmrnainhumanurinerevealssplicevariantbiomarkersofmusculardystrophies AT sofiageorghiou analysisofextracellularmrnainhumanurinerevealssplicevariantbiomarkersofmusculardystrophies AT basildarras analysisofextracellularmrnainhumanurinerevealssplicevariantbiomarkersofmusculardystrophies AT timclark analysisofextracellularmrnainhumanurinerevealssplicevariantbiomarkersofmusculardystrophies AT xandraobreakefield analysisofextracellularmrnainhumanurinerevealssplicevariantbiomarkersofmusculardystrophies AT thurmanmwheeler analysisofextracellularmrnainhumanurinerevealssplicevariantbiomarkersofmusculardystrophies
_version_	1718390434457190400

Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies

Ejemplares similares