Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence.

The development of amphetamine dependence largely depends on the effects of amphetamine in the brain reward systems. Ghrelin, an orexigenic peptide, activates the reward systems and is required for reward induced by alcohol, nicotine, cocaine and amphetamine in mice. Human genetic studies have shown...

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Autores principales:	Petra Suchankova, Elisabet Jerlhag, Nitya Jayaram-Lindström, Staffan Nilsson, Kjell Toren, Annika Rosengren, Jörgen A Engel, Johan Franck
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3668e1171f34b20833392811df04f45
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spelling	oai:doaj.org-article:a3668e1171f34b20833392811df04f452021-11-18T07:50:16ZGenetic variation of the ghrelin signalling system in individuals with amphetamine dependence.1932-620310.1371/journal.pone.0061242https://doaj.org/article/a3668e1171f34b20833392811df04f452013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23579732/?tool=EBIhttps://doaj.org/toc/1932-6203The development of amphetamine dependence largely depends on the effects of amphetamine in the brain reward systems. Ghrelin, an orexigenic peptide, activates the reward systems and is required for reward induced by alcohol, nicotine, cocaine and amphetamine in mice. Human genetic studies have shown that polymorphisms in the pre-proghrelin (GHRL) as well as GHS-R1A (GHSR) genes are associated with high alcohol consumption, increased weight and smoking in males. Since the heritability factor underlying drug dependence is shared between different drugs of abuse, we here examine the association between single nucleotide polymorphisms (SNPs) and haplotypes in the GHRL and GHSR, and amphetamine dependence. GHRL and GHSR SNPs were genotyped in Swedish amphetamine dependent individuals (n = 104) and controls from the general population (n = 310). A case-control analysis was performed and SNPs and haplotypes were additionally tested for association against Addiction Severity Interview (ASI) composite score of drug use. The minor G-allele of the GHSR SNP rs2948694, was more common among amphetamine dependent individuals when compared to controls (pc = 0.02). A significant association between the GHRL SNP rs4684677 and ASI composite score of drug use was also reported (pc = 0.03). The haplotype analysis did not add to the information given by the individual polymorphisms. Although genetic variability of the ghrelin signalling system is not a diagnostic marker for amphetamine dependence and problem severity of drug use, the present results strengthen the notion that ghrelin and its receptor may be involved in the development of addictive behaviours and may thus serve as suitable targets for new treatments of such disorders.Petra SuchankovaElisabet JerlhagNitya Jayaram-LindströmStaffan NilssonKjell TorenAnnika RosengrenJörgen A EngelJohan FranckPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61242 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Petra Suchankova Elisabet Jerlhag Nitya Jayaram-Lindström Staffan Nilsson Kjell Toren Annika Rosengren Jörgen A Engel Johan Franck Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence.
description	The development of amphetamine dependence largely depends on the effects of amphetamine in the brain reward systems. Ghrelin, an orexigenic peptide, activates the reward systems and is required for reward induced by alcohol, nicotine, cocaine and amphetamine in mice. Human genetic studies have shown that polymorphisms in the pre-proghrelin (GHRL) as well as GHS-R1A (GHSR) genes are associated with high alcohol consumption, increased weight and smoking in males. Since the heritability factor underlying drug dependence is shared between different drugs of abuse, we here examine the association between single nucleotide polymorphisms (SNPs) and haplotypes in the GHRL and GHSR, and amphetamine dependence. GHRL and GHSR SNPs were genotyped in Swedish amphetamine dependent individuals (n = 104) and controls from the general population (n = 310). A case-control analysis was performed and SNPs and haplotypes were additionally tested for association against Addiction Severity Interview (ASI) composite score of drug use. The minor G-allele of the GHSR SNP rs2948694, was more common among amphetamine dependent individuals when compared to controls (pc = 0.02). A significant association between the GHRL SNP rs4684677 and ASI composite score of drug use was also reported (pc = 0.03). The haplotype analysis did not add to the information given by the individual polymorphisms. Although genetic variability of the ghrelin signalling system is not a diagnostic marker for amphetamine dependence and problem severity of drug use, the present results strengthen the notion that ghrelin and its receptor may be involved in the development of addictive behaviours and may thus serve as suitable targets for new treatments of such disorders.
format	article
author	Petra Suchankova Elisabet Jerlhag Nitya Jayaram-Lindström Staffan Nilsson Kjell Toren Annika Rosengren Jörgen A Engel Johan Franck
author_facet	Petra Suchankova Elisabet Jerlhag Nitya Jayaram-Lindström Staffan Nilsson Kjell Toren Annika Rosengren Jörgen A Engel Johan Franck
author_sort	Petra Suchankova
title	Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence.
title_short	Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence.
title_full	Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence.
title_fullStr	Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence.
title_full_unstemmed	Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence.
title_sort	genetic variation of the ghrelin signalling system in individuals with amphetamine dependence.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a3668e1171f34b20833392811df04f45
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Genetic variation of the ghrelin signalling system in individuals with amphetamine dependence.

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