Determination of pharmacokinetic parameters and tissue distribution characters of enrofloxacin and its metabolite ciprofloxacin in Procambarus clarkii after two routes of administration

Enrofloxacin (ENR) is widely used for treatment and prevention of bacterial pathogen infections in aquatic animals. However, limited knowledge on kinetic disposal process of ENR in crayfish (Procambrus clarkii). Therefore, the objective of this study was to explore the pharmacokinetics (PK) and tiss...

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Autores principales:	Yong-Tao Liu, Guo-Dong Zhang, Ru-Yu Sun, Shu Zhou, Jing Dong, Yi-Bin Yang, Qiu-Hong Yang, Ning Xu, Xiao-Hui Ai
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Crayfish Enrofloxacin Ciprofloxacin Pharmacokinetics Tissue distribution Aquaculture. Fisheries. Angling SH1-691
Acceso en línea:	https://doaj.org/article/a38392ad8100416d8cf15a07cf304ac4
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spelling	oai:doaj.org-article:a38392ad8100416d8cf15a07cf304ac42021-11-10T04:28:47ZDetermination of pharmacokinetic parameters and tissue distribution characters of enrofloxacin and its metabolite ciprofloxacin in Procambarus clarkii after two routes of administration2352-513410.1016/j.aqrep.2021.100939https://doaj.org/article/a38392ad8100416d8cf15a07cf304ac42022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352513421003562https://doaj.org/toc/2352-5134Enrofloxacin (ENR) is widely used for treatment and prevention of bacterial pathogen infections in aquatic animals. However, limited knowledge on kinetic disposal process of ENR in crayfish (Procambrus clarkii). Therefore, the objective of this study was to explore the pharmacokinetics (PK) and tissue distribution regularities of ENR and its predominate metabolite, ciprofloxian (CIP), in crayfish following oral (PO) and intramuscular (IM) administrations. ENR and CIP concentrations in crayfish hemolymph and tissues were determined using ultra performance liquid chromatography coupled to fluorescence detection (UPLC-FLR). PK parameters of targets in hemolymph and tissues were calculated using WinNolin software based on the non-compartmental analysis. Comparative PK parameters in hemolymph showed that higher absorption and longer elimination half-life following IM route than PO treatment. For tissue distribution, high concentrations of ENR and CIP were found in hepatopancreas, and ENR and CIP levels in tissues after IM administration were higher than PO administration. The AUC0-∞ ratios of CIP and ENR in crayfish following PO and IM routes were only 1.25% and 3.56% (hemolymph), 0.71% and 6.89% (muscle), 1.03% and 1.75% (hepatopancreas), 0.65% and 6.46% (gill), respectively, and it indicated that crayfish has a low ability to transform ENR to CIP. ENR regimen suggested against susceptible strains with the minimum inhibition concentration (MIC) below 0.72 μg/mL (IM) and 0.50 μg/mL (PO) based on the values of Cmax/MIC > 8 and AUC/MIC > 125. It could serve as reference data for ENR use in crayfish and provide valuable information for the better utilization of ENR in aquatic animals.Yong-Tao LiuGuo-Dong ZhangRu-Yu SunShu ZhouJing DongYi-Bin YangQiu-Hong YangNing XuXiao-Hui AiElsevierarticleCrayfishEnrofloxacinCiprofloxacinPharmacokineticsTissue distributionAquaculture. Fisheries. AnglingSH1-691ENAquaculture Reports, Vol 22, Iss , Pp 100939- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Crayfish Enrofloxacin Ciprofloxacin Pharmacokinetics Tissue distribution Aquaculture. Fisheries. Angling SH1-691
spellingShingle	Crayfish Enrofloxacin Ciprofloxacin Pharmacokinetics Tissue distribution Aquaculture. Fisheries. Angling SH1-691 Yong-Tao Liu Guo-Dong Zhang Ru-Yu Sun Shu Zhou Jing Dong Yi-Bin Yang Qiu-Hong Yang Ning Xu Xiao-Hui Ai Determination of pharmacokinetic parameters and tissue distribution characters of enrofloxacin and its metabolite ciprofloxacin in Procambarus clarkii after two routes of administration
description	Enrofloxacin (ENR) is widely used for treatment and prevention of bacterial pathogen infections in aquatic animals. However, limited knowledge on kinetic disposal process of ENR in crayfish (Procambrus clarkii). Therefore, the objective of this study was to explore the pharmacokinetics (PK) and tissue distribution regularities of ENR and its predominate metabolite, ciprofloxian (CIP), in crayfish following oral (PO) and intramuscular (IM) administrations. ENR and CIP concentrations in crayfish hemolymph and tissues were determined using ultra performance liquid chromatography coupled to fluorescence detection (UPLC-FLR). PK parameters of targets in hemolymph and tissues were calculated using WinNolin software based on the non-compartmental analysis. Comparative PK parameters in hemolymph showed that higher absorption and longer elimination half-life following IM route than PO treatment. For tissue distribution, high concentrations of ENR and CIP were found in hepatopancreas, and ENR and CIP levels in tissues after IM administration were higher than PO administration. The AUC0-∞ ratios of CIP and ENR in crayfish following PO and IM routes were only 1.25% and 3.56% (hemolymph), 0.71% and 6.89% (muscle), 1.03% and 1.75% (hepatopancreas), 0.65% and 6.46% (gill), respectively, and it indicated that crayfish has a low ability to transform ENR to CIP. ENR regimen suggested against susceptible strains with the minimum inhibition concentration (MIC) below 0.72 μg/mL (IM) and 0.50 μg/mL (PO) based on the values of Cmax/MIC > 8 and AUC/MIC > 125. It could serve as reference data for ENR use in crayfish and provide valuable information for the better utilization of ENR in aquatic animals.
format	article
author	Yong-Tao Liu Guo-Dong Zhang Ru-Yu Sun Shu Zhou Jing Dong Yi-Bin Yang Qiu-Hong Yang Ning Xu Xiao-Hui Ai
author_facet	Yong-Tao Liu Guo-Dong Zhang Ru-Yu Sun Shu Zhou Jing Dong Yi-Bin Yang Qiu-Hong Yang Ning Xu Xiao-Hui Ai
author_sort	Yong-Tao Liu
title	Determination of pharmacokinetic parameters and tissue distribution characters of enrofloxacin and its metabolite ciprofloxacin in Procambarus clarkii after two routes of administration
title_short	Determination of pharmacokinetic parameters and tissue distribution characters of enrofloxacin and its metabolite ciprofloxacin in Procambarus clarkii after two routes of administration
title_full	Determination of pharmacokinetic parameters and tissue distribution characters of enrofloxacin and its metabolite ciprofloxacin in Procambarus clarkii after two routes of administration
title_fullStr	Determination of pharmacokinetic parameters and tissue distribution characters of enrofloxacin and its metabolite ciprofloxacin in Procambarus clarkii after two routes of administration
title_full_unstemmed	Determination of pharmacokinetic parameters and tissue distribution characters of enrofloxacin and its metabolite ciprofloxacin in Procambarus clarkii after two routes of administration
title_sort	determination of pharmacokinetic parameters and tissue distribution characters of enrofloxacin and its metabolite ciprofloxacin in procambarus clarkii after two routes of administration
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/a38392ad8100416d8cf15a07cf304ac4
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Determination of pharmacokinetic parameters and tissue distribution characters of enrofloxacin and its metabolite ciprofloxacin in Procambarus clarkii after two routes of administration

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