CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph
The immunology of Indigenous populations is generally understudied outside the context of diseases that are prevalent in these communities. Here the authors identify prevalence of influenza CD8+ T cell epitopes in an Indigenous Australian population expressing the susceptibility allomorph HLA A*24:0...
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Nature Portfolio
2021
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oai:doaj.org-article:a3a6a4c017e544c7b83819f5cde0c3d52021-12-02T16:51:19ZCD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph10.1038/s41467-021-23212-x2041-1723https://doaj.org/article/a3a6a4c017e544c7b83819f5cde0c3d52021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23212-xhttps://doaj.org/toc/2041-1723The immunology of Indigenous populations is generally understudied outside the context of diseases that are prevalent in these communities. Here the authors identify prevalence of influenza CD8+ T cell epitopes in an Indigenous Australian population expressing the susceptibility allomorph HLA A*24:02 and validate immunodominance of some of these epitopes in mice.Luca HensenPatricia T. IllingE. Bridie ClemensThi H. O. NguyenMarios KoutsakosCarolien E. van de SandtNicole A. MifsudAndrea T. NguyenChristopher SzetoBrendon Y. ChuaHanim HalimSimone RizzettoFabio LucianiLiyen LohEmma J. GrantPhillipa M. SaundersAndrew G. BrooksSteve RockmanTom C. KotsimbosAllen C. ChengMichael RichardsGlen P. WestallLinda M. WakimThomas LoudovarisStuart I. ManneringMichael ElliottStuart G. TangyeDavid C. JacksonKatie L. FlanaganJamie RossjohnStephanie GrasJane DaviesAdrian MillerSteven Y. C. TongAnthony W. PurcellKatherine KedzierskaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
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Science Q |
| spellingShingle |
Science Q Luca Hensen Patricia T. Illing E. Bridie Clemens Thi H. O. Nguyen Marios Koutsakos Carolien E. van de Sandt Nicole A. Mifsud Andrea T. Nguyen Christopher Szeto Brendon Y. Chua Hanim Halim Simone Rizzetto Fabio Luciani Liyen Loh Emma J. Grant Phillipa M. Saunders Andrew G. Brooks Steve Rockman Tom C. Kotsimbos Allen C. Cheng Michael Richards Glen P. Westall Linda M. Wakim Thomas Loudovaris Stuart I. Mannering Michael Elliott Stuart G. Tangye David C. Jackson Katie L. Flanagan Jamie Rossjohn Stephanie Gras Jane Davies Adrian Miller Steven Y. C. Tong Anthony W. Purcell Katherine Kedzierska CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph |
| description |
The immunology of Indigenous populations is generally understudied outside the context of diseases that are prevalent in these communities. Here the authors identify prevalence of influenza CD8+ T cell epitopes in an Indigenous Australian population expressing the susceptibility allomorph HLA A*24:02 and validate immunodominance of some of these epitopes in mice. |
| format |
article |
| author |
Luca Hensen Patricia T. Illing E. Bridie Clemens Thi H. O. Nguyen Marios Koutsakos Carolien E. van de Sandt Nicole A. Mifsud Andrea T. Nguyen Christopher Szeto Brendon Y. Chua Hanim Halim Simone Rizzetto Fabio Luciani Liyen Loh Emma J. Grant Phillipa M. Saunders Andrew G. Brooks Steve Rockman Tom C. Kotsimbos Allen C. Cheng Michael Richards Glen P. Westall Linda M. Wakim Thomas Loudovaris Stuart I. Mannering Michael Elliott Stuart G. Tangye David C. Jackson Katie L. Flanagan Jamie Rossjohn Stephanie Gras Jane Davies Adrian Miller Steven Y. C. Tong Anthony W. Purcell Katherine Kedzierska |
| author_facet |
Luca Hensen Patricia T. Illing E. Bridie Clemens Thi H. O. Nguyen Marios Koutsakos Carolien E. van de Sandt Nicole A. Mifsud Andrea T. Nguyen Christopher Szeto Brendon Y. Chua Hanim Halim Simone Rizzetto Fabio Luciani Liyen Loh Emma J. Grant Phillipa M. Saunders Andrew G. Brooks Steve Rockman Tom C. Kotsimbos Allen C. Cheng Michael Richards Glen P. Westall Linda M. Wakim Thomas Loudovaris Stuart I. Mannering Michael Elliott Stuart G. Tangye David C. Jackson Katie L. Flanagan Jamie Rossjohn Stephanie Gras Jane Davies Adrian Miller Steven Y. C. Tong Anthony W. Purcell Katherine Kedzierska |
| author_sort |
Luca Hensen |
| title |
CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph |
| title_short |
CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph |
| title_full |
CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph |
| title_fullStr |
CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph |
| title_full_unstemmed |
CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph |
| title_sort |
cd8+ t cell landscape in indigenous and non-indigenous people restricted by influenza mortality-associated hla-a*24:02 allomorph |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a3a6a4c017e544c7b83819f5cde0c3d5 |
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