Diversity-oriented synthesis of glycomimetics

Glycomimetics are structural mimics of carbohydrates that can replicate their biological activity but have improved drug-like properties. Here, using proline-catalysed α-halogenation/aldol cascades, carbohydrate building blocks are readily assembled and then diversified into glycomimetics including...

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Autores principales:	Michael Meanwell, Gaelen Fehr, Weiwu Ren, Bharanishashank Adluri, Victoria Rose, Johannes Lehmann, Steven M. Silverman, Rozhin Rowshanpour, Christopher Adamson, Milan Bergeron-Brlek, Hayden Foy, Venugopal Rao Challa, Louis-Charles Campeau, Travis Dudding, Robert Britton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a3c44d6cc42a4edc9776c757309987ae
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spelling	oai:doaj.org-article:a3c44d6cc42a4edc9776c757309987ae2021-12-02T17:44:51ZDiversity-oriented synthesis of glycomimetics10.1038/s42004-021-00520-32399-3669https://doaj.org/article/a3c44d6cc42a4edc9776c757309987ae2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00520-3https://doaj.org/toc/2399-3669Glycomimetics are structural mimics of carbohydrates that can replicate their biological activity but have improved drug-like properties. Here, using proline-catalysed α-halogenation/aldol cascades, carbohydrate building blocks are readily assembled and then diversified into glycomimetics including imino- and carbasugars.Michael MeanwellGaelen FehrWeiwu RenBharanishashank AdluriVictoria RoseJohannes LehmannSteven M. SilvermanRozhin RowshanpourChristopher AdamsonMilan Bergeron-BrlekHayden FoyVenugopal Rao ChallaLouis-Charles CampeauTravis DuddingRobert BrittonNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Michael Meanwell Gaelen Fehr Weiwu Ren Bharanishashank Adluri Victoria Rose Johannes Lehmann Steven M. Silverman Rozhin Rowshanpour Christopher Adamson Milan Bergeron-Brlek Hayden Foy Venugopal Rao Challa Louis-Charles Campeau Travis Dudding Robert Britton Diversity-oriented synthesis of glycomimetics
description	Glycomimetics are structural mimics of carbohydrates that can replicate their biological activity but have improved drug-like properties. Here, using proline-catalysed α-halogenation/aldol cascades, carbohydrate building blocks are readily assembled and then diversified into glycomimetics including imino- and carbasugars.
format	article
author	Michael Meanwell Gaelen Fehr Weiwu Ren Bharanishashank Adluri Victoria Rose Johannes Lehmann Steven M. Silverman Rozhin Rowshanpour Christopher Adamson Milan Bergeron-Brlek Hayden Foy Venugopal Rao Challa Louis-Charles Campeau Travis Dudding Robert Britton
author_facet	Michael Meanwell Gaelen Fehr Weiwu Ren Bharanishashank Adluri Victoria Rose Johannes Lehmann Steven M. Silverman Rozhin Rowshanpour Christopher Adamson Milan Bergeron-Brlek Hayden Foy Venugopal Rao Challa Louis-Charles Campeau Travis Dudding Robert Britton
author_sort	Michael Meanwell
title	Diversity-oriented synthesis of glycomimetics
title_short	Diversity-oriented synthesis of glycomimetics
title_full	Diversity-oriented synthesis of glycomimetics
title_fullStr	Diversity-oriented synthesis of glycomimetics
title_full_unstemmed	Diversity-oriented synthesis of glycomimetics
title_sort	diversity-oriented synthesis of glycomimetics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a3c44d6cc42a4edc9776c757309987ae
work_keys_str_mv	AT michaelmeanwell diversityorientedsynthesisofglycomimetics AT gaelenfehr diversityorientedsynthesisofglycomimetics AT weiwuren diversityorientedsynthesisofglycomimetics AT bharanishashankadluri diversityorientedsynthesisofglycomimetics AT victoriarose diversityorientedsynthesisofglycomimetics AT johanneslehmann diversityorientedsynthesisofglycomimetics AT stevenmsilverman diversityorientedsynthesisofglycomimetics AT rozhinrowshanpour diversityorientedsynthesisofglycomimetics AT christopheradamson diversityorientedsynthesisofglycomimetics AT milanbergeronbrlek diversityorientedsynthesisofglycomimetics AT haydenfoy diversityorientedsynthesisofglycomimetics AT venugopalraochalla diversityorientedsynthesisofglycomimetics AT louischarlescampeau diversityorientedsynthesisofglycomimetics AT travisdudding diversityorientedsynthesisofglycomimetics AT robertbritton diversityorientedsynthesisofglycomimetics
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Diversity-oriented synthesis of glycomimetics

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