Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems

Abstract Glucose is an essential energy source for cells. In humans, its passive diffusion through the cell membrane is facilitated by members of the glucose transporter family (GLUT, SLC2 gene family). GLUT2 transports both glucose and fructose with low affinity and plays a critical role in glucose...

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Autores principales: Sina Schmidl, Oleg Ursu, Cristina V. Iancu, Mislav Oreb, Tudor I. Oprea, Jun-yong Choe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a3ca6807862349959215bc5d361e1f6c
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