Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
Genetic variation in ANGPTL4 is associated with lipid traits. Here, the authors find that predicted loss-of-function variants in ANGPTL4 are associated with glucose homeostasis and reduced risk of type 2 diabetes and that Angptl4 −/− mice on a high-fat diet show improved insulin sensitivity.
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2018
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oai:doaj.org-article:a3d832a109514250b3a42f9eaa1a1b952021-12-02T15:33:43ZGenetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes10.1038/s41467-018-04611-z2041-1723https://doaj.org/article/a3d832a109514250b3a42f9eaa1a1b952018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04611-zhttps://doaj.org/toc/2041-1723Genetic variation in ANGPTL4 is associated with lipid traits. Here, the authors find that predicted loss-of-function variants in ANGPTL4 are associated with glucose homeostasis and reduced risk of type 2 diabetes and that Angptl4 −/− mice on a high-fat diet show improved insulin sensitivity.Viktoria GusarovaColm O’DushlaineTanya M. TeslovichPeter N. BenottiTooraj MirshahiOmri GottesmanCristopher V. Van HoutMichael F. MurrayAnubha MahajanJonas B. NielsenLars FritscheAnders Berg WulffDaniel F. GudbjartssonMarketa SjögrenConnor A. EmdinRobert A. ScottWen-Jane LeeAeron SmallLydia C. KweeOm Prakash DwivediRashmi B. PrasadShannon BruseAlexander E. LopezJohn PennAnthony MarckettaJoseph B. LeaderChristopher D. StillH. Lester KirchnerUyenlinh L. MirshahiAmr H. WardehCassandra M. HartleLukas HabeggerSamantha N. FetterolfTeresa Tusie-LunaAndrew P. MorrisHilma HolmValgerdur SteinthorsdottirPatrick SulemUnnur ThorsteinsdottirJerome I. RotterLee-Ming ChuangScott DamrauerDavid BirtwellChad M. BrummettAmit V. KheraPradeep NatarajanMarju Orho-MelanderJason FlannickLuca A. LottaCristen J. WillerOddgeir L. HolmenMarylyn D. RitchieDavid H. LedbetterAndrew J. MurphyIngrid B. BoreckiJeffrey G. ReidJohn D. OvertonOla HanssonLeif GroopSvati H. ShahWilliam E. KrausDaniel J. RaderYii-Der I. ChenKristian HveemNicholas J. WarehamSekar KathiresanOlle MelanderKari StefanssonBørge G. NordestgaardAnne Tybjærg-HansenGoncalo R. AbecasisDavid AltshulerJose C. FlorezMichael BoehnkeMark I. McCarthyGeorge D. YancopoulosDavid J. CareyAlan R. ShuldinerAris BarasFrederick E. DeweyJesper GromadaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Viktoria Gusarova Colm O’Dushlaine Tanya M. Teslovich Peter N. Benotti Tooraj Mirshahi Omri Gottesman Cristopher V. Van Hout Michael F. Murray Anubha Mahajan Jonas B. Nielsen Lars Fritsche Anders Berg Wulff Daniel F. Gudbjartsson Marketa Sjögren Connor A. Emdin Robert A. Scott Wen-Jane Lee Aeron Small Lydia C. Kwee Om Prakash Dwivedi Rashmi B. Prasad Shannon Bruse Alexander E. Lopez John Penn Anthony Marcketta Joseph B. Leader Christopher D. Still H. Lester Kirchner Uyenlinh L. Mirshahi Amr H. Wardeh Cassandra M. Hartle Lukas Habegger Samantha N. Fetterolf Teresa Tusie-Luna Andrew P. Morris Hilma Holm Valgerdur Steinthorsdottir Patrick Sulem Unnur Thorsteinsdottir Jerome I. Rotter Lee-Ming Chuang Scott Damrauer David Birtwell Chad M. Brummett Amit V. Khera Pradeep Natarajan Marju Orho-Melander Jason Flannick Luca A. Lotta Cristen J. Willer Oddgeir L. Holmen Marylyn D. Ritchie David H. Ledbetter Andrew J. Murphy Ingrid B. Borecki Jeffrey G. Reid John D. Overton Ola Hansson Leif Groop Svati H. Shah William E. Kraus Daniel J. Rader Yii-Der I. Chen Kristian Hveem Nicholas J. Wareham Sekar Kathiresan Olle Melander Kari Stefansson Børge G. Nordestgaard Anne Tybjærg-Hansen Goncalo R. Abecasis David Altshuler Jose C. Florez Michael Boehnke Mark I. McCarthy George D. Yancopoulos David J. Carey Alan R. Shuldiner Aris Baras Frederick E. Dewey Jesper Gromada Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes |
| description |
Genetic variation in ANGPTL4 is associated with lipid traits. Here, the authors find that predicted loss-of-function variants in ANGPTL4 are associated with glucose homeostasis and reduced risk of type 2 diabetes and that Angptl4 −/− mice on a high-fat diet show improved insulin sensitivity. |
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article |
| author |
Viktoria Gusarova Colm O’Dushlaine Tanya M. Teslovich Peter N. Benotti Tooraj Mirshahi Omri Gottesman Cristopher V. Van Hout Michael F. Murray Anubha Mahajan Jonas B. Nielsen Lars Fritsche Anders Berg Wulff Daniel F. Gudbjartsson Marketa Sjögren Connor A. Emdin Robert A. Scott Wen-Jane Lee Aeron Small Lydia C. Kwee Om Prakash Dwivedi Rashmi B. Prasad Shannon Bruse Alexander E. Lopez John Penn Anthony Marcketta Joseph B. Leader Christopher D. Still H. Lester Kirchner Uyenlinh L. Mirshahi Amr H. Wardeh Cassandra M. Hartle Lukas Habegger Samantha N. Fetterolf Teresa Tusie-Luna Andrew P. Morris Hilma Holm Valgerdur Steinthorsdottir Patrick Sulem Unnur Thorsteinsdottir Jerome I. Rotter Lee-Ming Chuang Scott Damrauer David Birtwell Chad M. Brummett Amit V. Khera Pradeep Natarajan Marju Orho-Melander Jason Flannick Luca A. Lotta Cristen J. Willer Oddgeir L. Holmen Marylyn D. Ritchie David H. Ledbetter Andrew J. Murphy Ingrid B. Borecki Jeffrey G. Reid John D. Overton Ola Hansson Leif Groop Svati H. Shah William E. Kraus Daniel J. Rader Yii-Der I. Chen Kristian Hveem Nicholas J. Wareham Sekar Kathiresan Olle Melander Kari Stefansson Børge G. Nordestgaard Anne Tybjærg-Hansen Goncalo R. Abecasis David Altshuler Jose C. Florez Michael Boehnke Mark I. McCarthy George D. Yancopoulos David J. Carey Alan R. Shuldiner Aris Baras Frederick E. Dewey Jesper Gromada |
| author_facet |
Viktoria Gusarova Colm O’Dushlaine Tanya M. Teslovich Peter N. Benotti Tooraj Mirshahi Omri Gottesman Cristopher V. Van Hout Michael F. Murray Anubha Mahajan Jonas B. Nielsen Lars Fritsche Anders Berg Wulff Daniel F. Gudbjartsson Marketa Sjögren Connor A. Emdin Robert A. Scott Wen-Jane Lee Aeron Small Lydia C. Kwee Om Prakash Dwivedi Rashmi B. Prasad Shannon Bruse Alexander E. Lopez John Penn Anthony Marcketta Joseph B. Leader Christopher D. Still H. Lester Kirchner Uyenlinh L. Mirshahi Amr H. Wardeh Cassandra M. Hartle Lukas Habegger Samantha N. Fetterolf Teresa Tusie-Luna Andrew P. Morris Hilma Holm Valgerdur Steinthorsdottir Patrick Sulem Unnur Thorsteinsdottir Jerome I. Rotter Lee-Ming Chuang Scott Damrauer David Birtwell Chad M. Brummett Amit V. Khera Pradeep Natarajan Marju Orho-Melander Jason Flannick Luca A. Lotta Cristen J. Willer Oddgeir L. Holmen Marylyn D. Ritchie David H. Ledbetter Andrew J. Murphy Ingrid B. Borecki Jeffrey G. Reid John D. Overton Ola Hansson Leif Groop Svati H. Shah William E. Kraus Daniel J. Rader Yii-Der I. Chen Kristian Hveem Nicholas J. Wareham Sekar Kathiresan Olle Melander Kari Stefansson Børge G. Nordestgaard Anne Tybjærg-Hansen Goncalo R. Abecasis David Altshuler Jose C. Florez Michael Boehnke Mark I. McCarthy George D. Yancopoulos David J. Carey Alan R. Shuldiner Aris Baras Frederick E. Dewey Jesper Gromada |
| author_sort |
Viktoria Gusarova |
| title |
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes |
| title_short |
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes |
| title_full |
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes |
| title_fullStr |
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes |
| title_full_unstemmed |
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes |
| title_sort |
genetic inactivation of angptl4 improves glucose homeostasis and is associated with reduced risk of diabetes |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/a3d832a109514250b3a42f9eaa1a1b95 |
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