Development of a structural epitope mimic: an idiotypic approach to HCV vaccine design
Abstract HCV vaccine development is stymied by the high genetic diversity of the virus and the variability of the envelope glycoproteins. One strategy to overcome this is to identify conserved, functionally important regions—such as the epitopes of broadly neutralizing antibodies (bNAbs)—and use the...
Saved in:
Main Authors: | Vanessa M. Cowton, Ania M. Owsianka, Valeria Fadda, Ana Maria Ortega-Prieto, Sarah J. Cole, Jane A. Potter, Jessica K. Skelton, Nathan Jeffrey, Caterina Di Lorenzo, Marcus Dorner, Garry L. Taylor, Arvind H. Patel |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
|
Subjects: | |
Online Access: | https://doaj.org/article/a3e8c908a1e3414390d0657b55f1aeda |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate.
by: Zhen-yong Keck, et al.
Published: (2012) -
Preparation of polyclonal and monoclonal anti-idiotypic antibodies against morphine-specific immunoglobulins
by: A. V. Trofimov, et al.
Published: (2020) -
PREPARATION AND PROPERTIES OF MURINE ANTI-IDIOTYPIC MONOCLONAL ANTIBODIES RECOGNIZING PRIMARY RABBIT POLYCLONAL ANTIBODIES AGAINST MORPHINE DERIVATIVES
by: A. V. Trofimov, et al.
Published: (2019) -
Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans
by: Felix Broecker, et al.
Published: (2016) -
The melibiose-derived glycation product mimics a unique epitope present in human and animal tissues
by: Magdalena Staniszewska, et al.
Published: (2021)