Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines

Strategies for enantioselective α-aminomethylation of carbonyl compounds rely on the chiral activation of stable ketones substrate. Here, the authors report a rhodium/chiral phosphoric acid cooperative catalysis for the three-component reaction of α-diazo ketones with alcohols and 1,3,5-triazines vi...

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Autores principales:	Jiuwei Che, Li Niu, Shikun Jia, Dong Xing, Wenhao Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a3ef597d4cc44ac5b8b287977fd5add3
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spelling	oai:doaj.org-article:a3ef597d4cc44ac5b8b287977fd5add32021-12-02T17:33:12ZEnantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines10.1038/s41467-020-15345-22041-1723https://doaj.org/article/a3ef597d4cc44ac5b8b287977fd5add32020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15345-2https://doaj.org/toc/2041-1723Strategies for enantioselective α-aminomethylation of carbonyl compounds rely on the chiral activation of stable ketones substrate. Here, the authors report a rhodium/chiral phosphoric acid cooperative catalysis for the three-component reaction of α-diazo ketones with alcohols and 1,3,5-triazines via imine chiral activation.Jiuwei CheLi NiuShikun JiaDong XingWenhao HuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiuwei Che Li Niu Shikun Jia Dong Xing Wenhao Hu Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
description	Strategies for enantioselective α-aminomethylation of carbonyl compounds rely on the chiral activation of stable ketones substrate. Here, the authors report a rhodium/chiral phosphoric acid cooperative catalysis for the three-component reaction of α-diazo ketones with alcohols and 1,3,5-triazines via imine chiral activation.
format	article
author	Jiuwei Che Li Niu Shikun Jia Dong Xing Wenhao Hu
author_facet	Jiuwei Che Li Niu Shikun Jia Dong Xing Wenhao Hu
author_sort	Jiuwei Che
title	Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
title_short	Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
title_full	Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
title_fullStr	Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
title_full_unstemmed	Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
title_sort	enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a3ef597d4cc44ac5b8b287977fd5add3
work_keys_str_mv	AT jiuweiche enantioselectivethreecomponentaminomethylationofadiazoketoneswithalcoholsand135triazines AT liniu enantioselectivethreecomponentaminomethylationofadiazoketoneswithalcoholsand135triazines AT shikunjia enantioselectivethreecomponentaminomethylationofadiazoketoneswithalcoholsand135triazines AT dongxing enantioselectivethreecomponentaminomethylationofadiazoketoneswithalcoholsand135triazines AT wenhaohu enantioselectivethreecomponentaminomethylationofadiazoketoneswithalcoholsand135triazines
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Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines

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