Cellular redox imbalance and changes of protein S-glutathionylation patterns are associated with senescence induced by oncogenic H-ras.

H-Ras oncogene requires deregulation of additional oncogenes or inactivation of tumor suppressor proteins to increase cell proliferation rate and transform cells. In fact, the expression of the constitutively activated H-RasV12 induces cell growth arrest and premature senescence, which act like barr...

Full description

Saved in:
Bibliographic Details
Main Authors: Tatiana Armeni, Luisa Ercolani, Lorena Urbanelli, Alessandro Magini, Francesca Magherini, Armanda Pugnaloni, Francesco Piva, Alessandra Modesti, Carla Emiliani, Giovanni Principato
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
R
Q
Online Access:https://doaj.org/article/a46c62e317d44a6f995b297a448da801
Tags: Add Tag
No Tags, Be the first to tag this record!