Endoplasmic Reticulum Stress Caused by Lipoprotein Accumulation Suppresses Immunity against Bacterial Pathogens and Contributes to Immunosenescence

ABSTRACT The unfolded protein response (UPR) is a stress response pathway that is activated upon increased unfolded and/or misfolded proteins in the endoplasmic reticulum (ER), and enhanced ER stress response prolongs life span and improves immunity. However, the mechanism by which ER stress affects...

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Auteurs principaux: Jogender Singh, Alejandro Aballay
Format: article
Langue:EN
Publié: American Society for Microbiology 2017
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Accès en ligne:https://doaj.org/article/a4b8b556e1c7474abb223f802397b863
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