Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology

Small molecule polyamines participate in diverse aspects of cell growth and differentiation and are known to regulate ion channel gating. Here authors reveal that cellular polyamines control nicotinic acetylcholine receptor (nAChR) biogenesis, and either catabolic degradation or inhibition of polyam...

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Bibliographic Details
Main Authors: Madhurima Dhara, Jose A. Matta, Min Lei, Daniel Knowland, Hong Yu, Shenyan Gu, David S. Bredt
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/a4d43b266fe844dd9fdeb0819c48ee18
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